Results 101 to 110 of about 6,719,355 (312)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
A product line for workflow management systems [PDF]
, 2004 This paper presents an ongoing research on the development of a component-based product line architecture for workflow management systems. The research includes a process to design the proposed product line, the population of the product with components,
Barroca, Leonor +4 more
core +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
High-quality assembly and methylome of a Tibetan wild tree peony genome (Paeonia ludlowii) reveal the evolution of giant genome architecture [PDF]
, 2023 Pei-Xuan Xiao +9 more
openalex +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Discussion on Integration of Data Warehouse and Big Data
Dianxin kexue, 2015 In view of the traditional enterprise couldn't use such unstructured data efficiently,a big data solutions based on integration of data warehouse and big data was discussed.Based on the theory of data warehouse construction and architecture of the next ...
Juan Yu
doaj
On the Road to Holistic Decision Making in Adaptive Security [PDF]
Technology Innovation Management Review, 2013 Security is a critical concern in today's software systems. Besides the interconnectivity and dynamic nature of network systems, the increasing complexity in modern software systems amplifies the complexity of IT security.
Mahsa Emami-Taba +2 more
doaj
09:03 a dozen years to make a state go virtual : LIDAR data use for 3D visualisation of the Maltese Islands [PDF]
, 2013 Creating a new modus operandi for 3D data analysis that covers an entire state is a endearing task which required considerable funding and the integration of various thematic domains that lent an operational hand to spatial analysis in the Maltese state.
Digital Landscape Architecture 2013 +1 more
core
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source