Results 81 to 90 of about 1,087,461 (268)
Architecture and Engineering, 2018 Biomimicry is an old approach, but in the scientific conceptualization is new, as an approach of innovation based on the emulation of Nature, in recent years, this approach brings many potential theories and innovations in the architecture field. Indeed,
Yassine Mohammed Benyoucef, Andrey Razin
doaj +1 more source
Astrocyte heterogeneity in brain metastases
Molecular Oncology, EarlyView.Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver +2 more
wiley +1 more source
Bajo el signo de la esvástica. La Exposición de Arquitectura Moderna alemana en España (1942)
Diacronie. Studi di Storia Contemporanea, 2014 In autumn of 1942, Barcelona received the Exhibition of Modern German Architecture, directed by Albert Speer. The objective of this exhibition was to show to European allies the pharaonic projects of Germany, the Europa’s future new capital, the new ...
Francesc Vilanova i Vila-Abadal es Profesor Titular de Historia Contemporánea en la Universidad Autónoma de Barcelona y Director del Archivo Carles Pi i Sunyer (Fundació Carles Pi i Sunyer d’Estudis Autonòmics i Locals, Barcelon). Miembro del Grup de Recerca en l’Època Franquista (GREF) y del Centre d’Estudis sobre les Èpoques Franquista i Democràtica (UAB-CEFID).
doaj
The problems of high-rise construction in St. Petersburg
Journal of Architecture and Urbanism, 2016 St. Petersburg’s strict limit on building height existed until the 1960s. A small loosening of restrictions occurred only at the end of the 19th century, which formed the “horizontal” silhouette of the city with a few spire accents, domes and factory ...
Leonid Lavrov, Fedor Perov
doaj +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Cultural landscape in theory. 1st Part: Centre, core and triangle [PDF]
Urbani Izziv, 2002 The article presents ideas about the close links between architectural forms in theory and practice, as well as the extraordinary ties between the aspects of various disciplines and architectural expression.
Borut Juvanec
doaj
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source