Results 81 to 90 of about 4,453,047 (296)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Miranda: Revue Pluridisciplinaire du Monde Anglophone, 2011 Intensive mobility of the factors of production (capital and work) is a major feature of the United States. Based on a geographical analysis, this paper describes the way in which the geographical mobility of capital (considered here as a driving force ...
Frédéric Leriche
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
NANO, 2020 Lasting eighteen hours and featuring umpteen locations, Twin Peaks: The Return spreads out across time and space in a manner rarely seen in David Lynch’s work. In short, it sprawls. This article explores how sprawl might be a useful term through which to
Richard Martin
doaj
Innovation in English Gothic Architecture: Risks, Impediments, and Opportunities
British Art Studies, 2017 This essay considers some of the practical and human situations that affected innovation in English medieval architecture. These included the scale of the Norman inheritance, the process of incremental construction, and the personal relationships that ...
Roger Stalley
doaj +1 more source
The Architecture of Accreditation [PDF]
, 2011 Accreditation systems can be analyzed in terms of the designer’s choices in three dimensions. One dimension is purpose of accreditation, where purpose may relate to program quality or quality of outcomes.
Conison, Jay
core +2 more sources
Janus: An Uncertain Cache Architecture to Cope with Side Channel Attacks
, 2017 Side channel attacks are a major class of attacks to crypto-systems. Attackers collect and analyze timing behavior, I/O data, or power consumption in these systems to undermine their effectiveness in protecting sensitive information.
Darabi, Mostafa +4 more
core +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Architecture for Analysis of Streaming Data
, 2018 While several attempts have been made to construct a scalable and flexible architecture for analysis of streaming data, no general model to tackle this task exists.
Hoque, Sheik, Miranskyy, Andriy
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source