Results 61 to 70 of about 1,087,461 (268)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Miranda: Revue Pluridisciplinaire du Monde Anglophone, 2011 Intensive mobility of the factors of production (capital and work) is a major feature of the United States. Based on a geographical analysis, this paper describes the way in which the geographical mobility of capital (considered here as a driving force ...
Frédéric Leriche
doaj +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
NANO, 2020 Lasting eighteen hours and featuring umpteen locations, Twin Peaks: The Return spreads out across time and space in a manner rarely seen in David Lynch’s work. In short, it sprawls. This article explores how sprawl might be a useful term through which to
Richard Martin
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Innovation in English Gothic Architecture: Risks, Impediments, and Opportunities
British Art Studies, 2017 This essay considers some of the practical and human situations that affected innovation in English medieval architecture. These included the scale of the Norman inheritance, the process of incremental construction, and the personal relationships that ...
Roger Stalley
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
FEBS Letters, EarlyView.The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile +8 more
wiley +1 more source
Discussion on Integration of Data Warehouse and Big Data
Dianxin kexue, 2015 In view of the traditional enterprise couldn't use such unstructured data efficiently,a big data solutions based on integration of data warehouse and big data was discussed.Based on the theory of data warehouse construction and architecture of the next ...
Juan Yu
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