Results 41 to 50 of about 1,167,537 (268)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Визуальная теология, 2022 In the architectural works of the leaders of the Russian avant-garde, the most acute innovative proposals are implemented without violating the framework of the historically established value-civilization format.
Mark Gurari / Марк Натанович Гурари
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Architectural decoration of the eastern frontier
Проект БайкалThe article presents the results of the study conducted by the authors with the support of the grant of the Russian Science Foundation “Military Theme in the Architectural and Spatial Development of the Far East”. Based on the materials of field surveys
Михаил Базилевич +1 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
The Structure of Space and Problems of Our Time
Проект БайкалSince antiquity the image of space as emptiness has been opposed to the image of material space filled with some essence. For a long time this role was played by the theories of ether.
Светлана Головня +1 more
doaj +1 more source
The Mysteries of Rural Architecture [PDF]
مسکن و محیط روستا, 2010 The rural architecture is all about house it starts with a house and yet it ends with a house. The rural house is quite simple and calm, but in the meanwhile it enjoys some complexity in the sense of wisdom.
doaj
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Intelligent Models and Architectures for Global Learning-Oriented Cooperation
IEEE AccessThis paper presents the design of intelligent models and architectures for global learning-oriented cooperation. The research work brings our current investigations towards the definition of a general development methodology for global intelligent ...
Ana M. Gonzalez de Miguel +1 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source