Results 71 to 80 of about 1,071,418 (268)

On the Road to Holistic Decision Making in Adaptive Security [PDF]

open access: yesTechnology Innovation Management Review, 2013
Security is a critical concern in today's software systems. Besides the interconnectivity and dynamic nature of network systems, the increasing complexity in modern software systems amplifies the complexity of IT security.
Mahsa Emami-Taba   +2 more
doaj  

The ethnological and anthropological study of Bežanija at the start of the 21st century: The impact of urban development on boundaries and the perception of a neighbourhood [PDF]

open access: yesNasleđe, 2020
Being one of the older settlements in the present-day City of Belgrade, more precisely the municipality of Novi Beograd, Bežanija is a place boasting rich historical, urban planning, and architectural features.
Dražeta Bogdan D., Stankić Mladen D.
doaj  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

1951-1952 competition for the Monument to the fallen Jewish soldiers and victims of fascism in the Sephardi cemetery in Belgrade [PDF]

open access: yesNasleđe, 2020
In their wish to preserve the memory to the compatriots who lost their lives in the Holocaust, the Jewish community in Yugoslavia started erecting monuments to Jewish civil victims and fallen soldiers as early as the first few post-WWII years.
Stipić Davor
doaj  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Ludwig Hilberseimer and Metropolisarchitecture: The Analogue, the Blasé Attitude, the Multitude

open access: yesArts, 2018
This article close-reads Modernist architect Ludwig Hilberseimer’s early architectural projects, which employed a language of uniform fenestration, repetition and geometrically reduced typical forms, as embodying Georg Simmel’s blasé ...
Cameron McEwan
doaj   +1 more source

On the Interplay of Organizational Architecture and Software Architecture

open access: yesEnterp. Model. Inf. Syst. Archit., 2008
Enterprise Modelling and Information Systems Architectures, Vol 3, No 1 (2008)
Ganczarski, Wojciech, Winter, Robert
openaire   +3 more sources

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

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