Results 101 to 110 of about 21,696 (268)
Advanced Science, EarlyView.MDM2 dependency in pediatric sarcomas is driven by a novel p53‐independent oncogenic cistrome alongside canonical p53 pathway suppression. This study introduces MDM2‐recruiting transcriptional and epigenetic machinery degraders (MDM2‐TEMADs) as a novel precision oncology modality.
Jiawei Zhou +21 more
wiley +1 more source
Advanced Science, EarlyView.This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li +14 more
wiley +1 more source
NFYB Integrates Hormonal Signals into Tissue Allometry by Promoting Protein Biosynthesis
Advanced Science, EarlyView.In the American cockroach, NFYB acts as a spatiotemporin that translates distinct hormonal cues into tissue‐specific allometry. Juvenile hormone activates NFYB in the early fat body, while 20‐hydroxyecdysone induces it in late wing pads. NFYB then promotes protein biosynthesis via core translational machinery, driving differential growth across the ...
Fangfang Liu +11 more
wiley +1 more source
Advanced Science, EarlyView.This study establishes a CT‐based radiomics framework to quantify intratumoral heterogeneity (ITH) in HNSCC. Using unsupervised clustering, tumor ROIs and VOIs are analyzed to calculate 2D/3D ITH scores. The score shows strong predictive value for prognosis and immunotherapy response, and is associated with tumor metabolism and immune microenvironment,
Xinwei Chen +15 more
wiley +1 more source
Advanced Science, EarlyView.SSR4, a TRAP component induced in B cells, governs BAFFR N‐glycosylation via DDOST to sustain NF‐κB signaling, B‐cell differentiation, and TLS maturation. Its loss impairs anti‐tumor immunity, while overexpression improves antibody glycosylation and ADCC, revealing a critical regulator for cancer immunotherapy.
Wei Zhao +15 more
wiley +1 more source
Atlanti +, 2019 In this paper the author is convinced that today is the time when archival science can be defined in detail or even redefined. In professional archival literature we can find many definitions of archival science, which we can accept or take knowledge of without problems.
openaire +2 more sources
NAT10‐Mediated ac4C Modification of circANKRD12 Reprograms the Tumor Microenvironment
Advanced Science, EarlyView.NAT10‐dependent acetylation of circANKRD12 drives translation of the circANKRD12_354aa protein, which binds HDAC2 to stabilize c‐Myc via deubiquitination, promoting multiple myeloma (MM) cell proliferation. Concurrently, the circANKRD12‐HDAC2 axis suppresses H3ac‐mediated transcription of IFN‐γ, TNF‐α, and GZMB in NK cells, leading to NK cell ...
Jiale Zhang +8 more
wiley +1 more source
Renal IGFBP6 Interacts With THBS1 to Drive Renal Cellular Senescence and Fibrosis
Advanced Science, EarlyView.ABSTRACT Epithelial dedifferentiation and myofibroblast activation are critical drivers of chronic kidney disease (CKD) progression. Elevated levels of IGFBP6 have been linked to decreased renal function in CKD patients, but its precise role and underlying mechanisms remain unclear.
Ju‐tao Yu +26 more
wiley +1 more source
Advanced Science, EarlyView.We developed the ASCAL pipeline, integrating complementary spatial transcriptomics, to construct a high‐fidelity mouse whole‐eye single‐cell atlas. Applying ASCAL to a retinal artery occlusion (RAO) model revealed spatially restricted immune activation localized to the ganglion cell layer and the selective depletion of a translationally active, outer ...
Chen Du +11 more
wiley +1 more source
Personal archives and the boundaries of the archival science
Gragoatá, 2005 The article discusses some particularities of personal archives, focusing archival science principles as a whole. Personal archives, due to the fact of being more susceptible to have their custody interrupted by the heirs and due to being constituted by materials related to personal interests of their owners, which mean that they cannot be generalized,
openaire +2 more sources