Results 111 to 120 of about 36,168 (305)

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Time of archival science

, 2005
Agustín Vivas Moreno: El tiempo de la archivística: un estudio de sus espacios de racionalidad histórica http://www.ibict.br/cienciadainformacao/include/getdoc.php?id=1268&article=684&mode=pdf English Abstract: The main objective of this proposal is to ...
Klaus Graf
core   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Archival systems in the context of science

, 2000
The concept of systems accounts for the organization and patterns of order that characterize the natural world. Throughout the history of science, scientific activity has been based on this concept, either implicitly under a mechanistic approach or ...
Rodgers, Diane Margaret
core  

Exploring archival absence : silences, imagined records and materiality in nineteenth-century Europe

This article analyses archivists’ and historians’ experiences of archival absence innineteenth-century Europe. It takes off in well-known processes of centralisation,nationalisation and dislocations of archives to discuss how experiences of ...
Hagström Molin, Emma
core   +1 more source

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source

Artificial Intelligence in Recordkeeping

Khizanah al-Hikmah
This study presents a systematic literature review (SLR) of scholarly research published between 2014 and 2023, with the aim of identifying prevailing trends, methodological approaches, and contextual factors surrounding the use of Machine Learning (ML ...
Sigit Sumarsono, Muhamad Prabu Wibowo
doaj   +1 more source

A Perspective on Interactive Theorem Provers in Physics

Advanced Science, EarlyView.
Into an interactive theorem provers (ITPs), one can write mathematical definitions, theorems and proofs, and the correctness of those results is automatically checked. This perspective goes over the best usage of ITPs within physics and motivates the open‐source community run project PhysLean, the aim of which is to be a library for digitalized physics
Joseph Tooby‐Smith
wiley   +1 more source

The SDSS Science Archive [PDF]

Symposium - International Astronomical Union, 1997
Designing and implementing the Science Archive for the Sloan Digital Sky Survey (Gunn et. al 1992) has presented several unique architectural obstacles. First, the final archive will be large; the cumulative data products will exceed tens of Terabytes. Second, the data will be complex; extracted parameter catalogs will contain links to images, spectra,
openaire   +1 more source

Physical Origin of Temperature Induced Activation Energy Switching in Electrically Conductive Cement

Advanced Science, EarlyView.
The temperature‐induced Arrhenius activation energy switching phenomenon of electrical conduction in electrically conductive cement originates from structural degradation within the biphasic ionic‐electronic conduction architecture and shows percolation‐governed characteristics: pore network opening dominates the low‐percolation regime with downward ...
Jiacheng Zhang, Xinyuan Ke, Andrew Heath, Richard J. Ball, Jiawei Xie, Jinchen Fan, Guisheng Li, Kevin Paine   +7 more
wiley   +1 more source