Results 131 to 140 of about 283,865 (345)

Using semantic indexing to improve searching performance in web archives [PDF]

, 2013
The sheer volume of electronic documents being published on the Web can be overwhelming for users if the searching aspect is not properly addressed. This problem is particularly acute inside archives and repositories containing large collections of web ...
Khan, Arshad, Martin, David J., Tiropanis, Thanassis   +2 more
core  

RUNX2 Activation in Fibro/Adipogenic Progenitors Promotes Muscle Fibrosis in Muscular Dystrophy

Advanced Science, EarlyView.
This study revealed a novel role of the chemokine‐TGF‐β1‐RUNX2 axis in determining the fate of FAP differentiation and modulating muscle fibrosis in patients and mice with muscular dystrophies. ABSTRACT Clinical evidence indicates concurrent muscle inflammation and fibrosis in muscular dystrophies (MDs); however, the molecular mechanisms underlying ...
Pengkai Wu, Zehua Zhang, Kai Zheng, Ziqi Zhu, Yong Zhu, Abdukahar Kiram, Lei Zhao, Huihui Chen, Zhu Xu, Xihua Li, Beicheng Sun, Zhijian Li, Dengqiu Xu   +12 more
wiley   +1 more source

An assessment of the legal and regulatory framework supporting the implementation of the National Integrated Identity Management System (NIIMS) in Kenya

Data & Policy
This study sought to establish the elements that constitute comprehensive legal and regulatory landscape for successful digital identity system establishment and implementation. Subsequently, the study sought to assess whether these elements were present
Victor Kabata
doaj   +1 more source

DMITRY NIKOLAEVICH USHAKOV’ PERSONAL PAPERS IN THE ARCHIVE OF THE RUSSIAN ACADEMY OF SCIENCES

, 2023
О.В. Селиванова
openalex   +1 more source

Intercellular Horizontal Transfer of TXNDC5 mRNA via Extracellular Vesicles Contributes to Tumor‐Associated Macrophage‐Mediated Prostate Cancer Metastasis

Advanced Science, EarlyView.
This study investigates the role of M2 macrophage‐derived extracellular vesicles (M2 EVs) in prostate cancer (PCa) metastasis. Mechanistically, M2 EVs horizontally transfer TXNDC5 mRNA to PCa cells, where the molecule induces the mesenchymal‐like state (MLS), enhancing PCa migration and invasion.
Cong Hu, Tianyang Wu, Jiayi Wang, Xinxing Du, Xinrui Wu, Yanhao Dong, Zehong Peng, Penghui Liao, Zirui Guo, Zheyu Liu, Kenneth J Pienta, Yinjie Zhu, Jiahua Pan, Liang Dong, Wei Xue   +14 more
wiley   +1 more source

Wfau Science Archives: Facilitating Survey Science

, 2015
The Wide-Field Astronomy Unit in Edinburgh (WFAU) specializes in building and operating survey science archives. Imaging surveys carried out on UKIRT/WFCAM, VISTA/VIRCAM and the VST/OmegaCAM account for most of our current work, although we also operate the archive for the Gaia-ESO Spectroscopic survey.
openaire   +1 more source

Discusiones epistemológicas en torno a la cientificidad de la Archivología [PDF]

, 2015
This research is based on the premise that the strategies raised in defending the scientific status of the archival science are poorly made. It will not reach a status of science through the strategies of establishing paradigms, an object, a method, a ...
Alonso, Lucia, Noble, Luis, Saraiva, Ignacio   +2 more
core  

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Preserving Film Preservation in the Digital Era [PDF]

, 2013
This paper explores the current controversies surrounding film preservation in the digital era. Questions address the benefits of new technologies and the potential sacrifices to a film\u27s authenticity and designation as a valued historical, social ...
Bastron, Becca
core   +1 more source

Genomics Insights Into High‐Latitude Adaptation of Tibetan Macaques

Advanced Science, EarlyView.
Tibetan macaques exhibit unique adaptations to cold, high‐latitude environments, including shortened tails and enhanced fat storage. Genomic analyses reveal a species‐specific TBX6 mutation linked to tail reduction and selection on lipid metabolism genes.
Rusong Zhang, Ying Hu, Yang Teng, Jiwei Qi, Yangzhen Ciren, Lin Zhang, Qiao Du, Wencai Xu, Liang Zhou, Zhenxin Fan, Jinchuan Xing, Ming Li, Jing Li   +12 more
wiley   +1 more source