Results 131 to 140 of about 680,036 (364)
Measurements of the dissolved inorganic carbon system and associated biogeochemical parameters in the Canadian Arctic, 1974–2009 [PDF]
, 2014 Karina E. Giesbrecht +11 more
openalex +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
An Arctic-Tibetan Connection on Subseasonal to Seasonal Time Scale [PDF]
, 2019 Recent research indicates the great potentials of springtime land surface temperature (LST) as a new source of predictability to improve the subseasonal to seasonal climate prediction.
Xue, Y, Zhang, Y, Zou, T
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Variability in river temperature, discharge, and energy flux from the Russian pan‐Arctic landmass [PDF]
, 2007 We introduce a new Arctic river temperature data set covering 20 gauges in 17 unique Arctic Ocean drainage basins in the Russian pan‐Arctic (ART‐Russia).
Lammers, Richard B. +2 more
core +2 more sources
FEBS Open Bio, EarlyView.Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama +7 more
wiley +1 more source
True North: songs of the Arctic [PDF]
, 2016 This work consists of a 4-movement piece for orchestra, commissioned by the New Jersey Youth Symphony. The music is inspired by an expeditionary residency to the high arctic region of Svalbard led by The Arctic Circle organization.
LaRocca, Matthew Paul
core +1 more source
HSP70 governs permeability and mechanotransduction in primary human endothelial cells
FEBS Open Bio, EarlyView.HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez +5 more
wiley +1 more source
Sustainable Development, Natural Resource Extraction, and the Arctic: The Road Ahead [PDF]
, 2016 Sustainable development has emerged as an integral nexus, linking together critically important global issues including environmental stewardship and economic growth. Understanding sustainable development demands a close analysis of evolving definitions,
Canuel, Edward
core +1 more source