Results 111 to 120 of about 224,070 (269)
A Review of Foreign Arctic Research Based on ScienceDirect Database (2007—2021)
Haiyang Kaifa yu guanli, 2023 With the increasing melting of Arctic sea ice, the importance of studying Arctic issues is becoming more and more prominent. By using ScienceDirect database as the main search scope, the authors systematically combed foreign literature on Arctic issues ...
Zhenfu LI, Jia CHEN, Fei XUE
doaj
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
The Arctic Ocean Review Project (AOR): PHASE I REPORT 2009-2011 [PDF]
, 2011 The Arctic Ocean Review has been organized as a project under the Protection of the Arctic Marine Environment (PAME) working group of the Arctic Council, reporting to the Senior Arctic Officials (SAOs) of the Arctic Council through PAME. Subject to the
Arctic Council, Protection of the Arctic Marine Environment (PAME)
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
An Assessment of Emissions and Mitigation Options for Black Carbon for the Arctic Council; Technical Report of the Arctic Council Task Force on Short´Lived Climate Forcers [PDF]
, 2011 An Assessment of Emissions and Mitigation Options for Black Carbon for the Arctic Council is a report of the Arctic Council Task Force on Short-Lived Climate Forcers.
DeAngelo, Benjamin Ed.
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
International Journal of Circumpolar Health, 2018 Background: When people in Northern Norway get ill, they often use traditional medicine. The global aim of this study was to examine the extended family networks’ function and responsibility in cases of illness in the family, in two Northern Norwegian ...
Anette Langås-Larsen +5 more
doaj +1 more source
CAFF Technical Report No.3 - Atlas of Rare Endemic Vascular Plants of the Arctic [PDF]
, 1999 Atlas of Rare Endemic Vascular Plants of the Arctic is the Arctic Council's CAFF Working Group's Technical Report No ...
Arctic Council , Conservation of Arctic Flora and Fauna Working Group
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
CAFF Habitat Conservation report No.1 - The State of Protected Areas in the Circumpolar Arctic [PDF]
, 1994 The State of Protected Areas in the Circumpolar Arctic, 1994. Arctic council's CAFF Working Group's Habitat Conservation report No.
Arctic Council , Conservation of Arctic Flora and Fauna Working Group
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