Results 111 to 120 of about 273,435 (319)

Bacterial Diversity and Composition in the Internal Organs of Taiga Bean Goose, Greater White-Fronted Goose and Willow Ptarmigan as a New Tools in the Arctic Biomonitoring System

Diversity
Birds, fish, and marine mammals consumed by indigenous people are included in Arctic biomonitoring. However, there are still many gaps in the data on the microbiota associated with these animals.
Evdokia Durnova, Elena Karmanova, Tatiana Sorokina, Ksenia Mayorova, Andrey Aksenov   +4 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Assessments in Policy-Making: Case Studies from the Arctic Council [PDF]

, 2014
Julkaistu versioei tietoa ...
Kankaanpää, Paula, Banul, Karolina, Stępień, Adam, Śmieszek, Małgorzata, Lesser, Pamela, Koivurova, Timo   +5 more
core  

Effects of resource availability and interspecific interactions on Arctic and red foxes' winter use of ungulate carrion in the Fennoscandian low‐Arctic tundra

Ecology and Evolution
In the Arctic tundra, predators face recurrent periods of food scarcity and often turn to ungulate carcasses as an alternative food source. As important and localized resource patches, carrion promotes co‐occurrence of different individuals, and its use ...
Simon Lacombe, Rolf Ims, Nigel Yoccoz, Eivind Flittie Kleiven, Pedro G. Nicolau, Dorothee Ehrich   +5 more
doaj   +1 more source

A Review of Foreign Arctic Research Based on ScienceDirect Database (2007—2021)

Haiyang Kaifa yu guanli, 2023
With the increasing melting of Arctic sea ice, the importance of studying Arctic issues is becoming more and more prominent. By using ScienceDirect database as the main search scope, the authors systematically combed foreign literature on Arctic issues ...
Zhenfu LI, Jia CHEN, Fei XUE
doaj  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

The Arctic Ocean Review Project (AOR): PHASE I REPORT 2009-2011 [PDF]

, 2011
The Arctic Ocean Review has been organized as a project under the Protection of the Arctic Marine Environment (PAME) working group of the Arctic Council, reporting to the Senior Arctic Officials (SAOs) of the Arctic Council through PAME. Subject to the
Arctic Council, Protection of the Arctic Marine Environment (PAME)
core  

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

An Assessment of Emissions and Mitigation Options for Black Carbon for the Arctic Council; Technical Report of the Arctic Council Task Force on Short´Lived Climate Forcers [PDF]

, 2011
An Assessment of Emissions and Mitigation Options for Black Carbon for the Arctic Council is a report of the Arctic Council Task Force on Short-Lived Climate Forcers.
DeAngelo, Benjamin Ed.
core  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source