Results 91 to 100 of about 336,642 (296)

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Agreement on Cooperation on Aeronautical and Maritime Search and Rescue in the Arctic [PDF]

, 2011
Agreement on Cooperation on Aeronautical and Maritime Search and Rescue in the Arctic - The SAR Agreement is the first legally binding agreement established under the auspices of the Arctic Council.
Arctic Council, -
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

The prospective development of Climate and Environmental Research Laboratory of AARI, Roshydromet, after gaining the grant of Russian Science Foundation

Лëд и снег, 2015
In November 2010 a new research unit was inaugurated in Arctic and Antarctic Research Institute (St. Petersburg) – Climate and Environmental Research Laboratory (CERL) – that became the first lab in Russia dedicated to the complex studies of ice cores ...
V. Ya. Lipenkov, A. A. Ekaykin, Yu. A. Shibaev, I. A. Alekhina, A. V. Preobrazhenskaya, A. V. Kozachek, D. O. Vladimirova   +6 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

REYKJAVÍK DECLARATION 2004 On the occasion of the 4th Ministerial Meeting of the Arctic Council [PDF]

, 2004
REYKJAVÍK DECLARATION On the occasion of the Fourth Ministerial Meeting of the Arctic Council, 24 November 2004 in Reykjavík ...
Arctic Council, -
core   +1 more source

Inoculation of seed with strains of nitrogen-fixing bacteria (exampled by oats and millet) [PDF]

BIO Web of Conferences
As a result of the conducted researches the expediency and effectiveness of pre-sowing inoculation of seeds of field crops with strains of nitrogen-fixing bacteria has been proved, which allows to increase fodder productivity of oat and pearl millet ...
Osipova Valentina, Platonova Agafya, Khiterkheeva Nadezhda, Drincha Vasily, Dondokov Yuri, Nikolaeva Fevronya, Matveev Ivan, Druzyanova Varvara   +7 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Bacterial Diversity and Composition in the Internal Organs of Taiga Bean Goose, Greater White-Fronted Goose and Willow Ptarmigan as a New Tools in the Arctic Biomonitoring System

Diversity
Birds, fish, and marine mammals consumed by indigenous people are included in Arctic biomonitoring. However, there are still many gaps in the data on the microbiota associated with these animals.
Evdokia Durnova, Elena Karmanova, Tatiana Sorokina, Ksenia Mayorova, Andrey Aksenov   +4 more
doaj   +1 more source