Results 101 to 110 of about 224,070 (269)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Arctic Marine Shipping Assessment 2009 Report [PDF]

, 2009
This report discusses the current and future Arctic marine activity.
Arctic Council. Protection of the Arctic Marine Environment Working Group., Arctic Council, Protection of the Arctic Marine Environment (PAME)   +1 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

ARCTIC FLORA AND FAUNA: Status and Conservation [PDF]

, 2001
This report draws on the diversity of projects that the Program for the Conservation of Arctic Flora and Fauna (CAFF) has undertaken in its first decade, underscoring the need to address conservation on a circumpolar basis.
Arctic Council, Conservation of Arctic Flora and Fauna Working Group
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Effects of resource availability and interspecific interactions on Arctic and red foxes' winter use of ungulate carrion in the Fennoscandian low‐Arctic tundra

Ecology and Evolution
In the Arctic tundra, predators face recurrent periods of food scarcity and often turn to ungulate carcasses as an alternative food source. As important and localized resource patches, carrion promotes co‐occurrence of different individuals, and its use ...
Simon Lacombe, Rolf Ims, Nigel Yoccoz, Eivind Flittie Kleiven, Pedro G. Nicolau, Dorothee Ehrich   +5 more
doaj   +1 more source

Bacterial Diversity and Composition in the Internal Organs of Taiga Bean Goose, Greater White-Fronted Goose and Willow Ptarmigan as a New Tools in the Arctic Biomonitoring System

Diversity
Birds, fish, and marine mammals consumed by indigenous people are included in Arctic biomonitoring. However, there are still many gaps in the data on the microbiota associated with these animals.
Evdokia Durnova, Elena Karmanova, Tatiana Sorokina, Ksenia Mayorova, Andrey Aksenov   +4 more
doaj   +1 more source

Arctic Monitoring and Assessment Programme Assessment 2013: Arctic Ocean Acidification

, 2013
Report documenting the findings and recommendations of the first comprehensive assessment of Arctic Ocean acidification (AOA) conducted by the Arctic Monitoring and Assessment Programme (AMAP).
Arctic Monitoring and Assessment Programme
core  

Arctic Flora and Fauna: Recommendations for Conservation [PDF]

, 2002
This booklet contains a series of thematic goals and recommendations arising from Arctic Flora and Fauna: Status and Conservation , the science-based overview of Arctic biodiversity and key conservation issues published by CAFF in ...
Arctic Council , Conservation of Arctic Flora and Fauna Working Group
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source