Results 81 to 90 of about 336,642 (296)

NEW PALEOGEOGRAPHY DATA OF THE EASTERN COAST OF GREEN FJORD (WEST SPITSBERGEN ISLAND) BASED ON RESEARCH OF THE HOLOCENE DEPOSITS ON FINNESET CAPE WITH USE OF ISOTOPE-GEOCHEMICAL METHODS

open access: yesИзвестия Томского политехнического университета: Инжиниринг георесурсов, 2020
The relevance of the research consists in determining the age of mollusks in the Green fjord bay of West Spitsbergen Island and physical and chemical parameters of their habitant environment in conditions of the threat of destruction of geological ...
Vidas V. Kriauciunas   +6 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

BARROW DECLARATION 2000 on the occasion of the Second Ministerial Meeting of THE ARCTIC COUNCIL [PDF]

open access: yes, 2000
BARROW DECLARATION on the occasion of the Second Ministerial Meeting of THE ARCTIC COUNCIL, October ...
Arctic Council, -
core   +1 more source

INARI DECLARATION 2002 on the occasion of the Third Ministerial Meeting of THE ARCTIC COUNCIL [PDF]

open access: yes, 2002
INARI DECLARATION on the occasion of the Third Ministerial Meeting of THE ARCTIC COUNCIL, October ...
Arctic Council, -
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

Development of a methodology for automated processing of spatial data of agricultural land based on machine learning [PDF]

open access: yesE3S Web of Conferences
Agriculture industry in Russia is an important part of the economy. Therefore, this industry must be highly efficient and profitable. The usage of remote sensing data for field monitoring makes it possible to simplify the process of collecting ...
Berezovsky Vladimir   +3 more
doaj   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

open access: yesMolecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both   +7 more
wiley   +1 more source

The Inuvik Declaration, 1996. Declaration from the Ministerial meeting of the Arctic Environmental Protection Strategy (AEPS)held in Inuvik, Canada. [PDF]

open access: yes, 1996
The Inuvik Declaration, March 21,1996. Declaration from the Ministerial meeting of the Arctic Environmental Protection Strategy (AEPS)held in Inuvik, Canada.
Arctic Council, -
core   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

open access: yesMolecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler   +3 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

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