Results 121 to 130 of about 224,070 (269)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

CAFF habitat Conservation Report No.2 - Proposed Protected Areas in the Circumpolar Arctic [PDF]

open access: yes, 1996
Proposed Protected Areas in the Circumpolar Arctic - 1996 Arctic Council's CAFF Working Group Habitat Conservation Report No.
Arctic Council , Conservation of Arctic Flora and Fauna Working Group
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

AOR - Arctic Ocean review project 2009-2013 brochure [PDF]

open access: yes, 2010
AOR - Arctic Ocean review project 2009-2013 - project ...
Arctic Council, Protection of the Arctic Marine Environment (PAME)
core  

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

open access: yesFEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth   +6 more
wiley   +1 more source

Russia – Arctic

open access: yes
Russia is the largest Arctic country, with a territory covering more than half of the Arctic Ocean coastline and 2.5 million Arctic inhabitants. The Arctic constitutes an integral element of Russia's identity, economic development, military and environmental security.
openaire   +1 more source

Arctic Ocean Acidification 2013: An Overview

open access: yes, 2014
Report presenting a summary of the first comprehensive assessment of Arctic Ocean acidification (AOA) conducted by the Arctic Monitoring and Assessment Programme (AMAP).
Arctic Monitoring and Assessment Programme
core  

CAFF Technical Report No.1 - Incidental Take of Seabirds in Commercial Fisheries in the Arctic Countries [PDF]

open access: yes, 1998
Incidental Take of Seabirds in Commercial Fisheries in the Arctic Countries is the Arctic Council's CAFF Working Group's Technical Report No.1, published 1998.
Arctic Council , Conservation of Arctic Flora and Fauna Working Group
core  

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

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