Results 61 to 70 of about 7,934 (246)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Arctic warming in response to regional aerosol emissions reductions
Environmental Research: Climate, 2023 This study examines the Arctic surface air temperature response to regional aerosol emissions reductions using three fully coupled chemistry–climate models: National Center for Atmospheric Research-Community Earth System Model version 1, Geophysical ...
Michael Previdi +6 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
The Effect of Arctic Sea‐Ice Loss on Extratropical Cyclones
Geophysical Research Letters, 2023 Taking advantage of the Polar Amplification Model Intercomparison Project simulations and using a Lagrangian objective feature tracking algorithm, we determine the response of extratropical cyclones to sea‐ice loss and consequent weakening of the equator‐
Stephanie Hay +4 more
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Role of Horizontal Heat Advection in Arctic Surface Warming During Early Spring
Geophysical Research Letters, 2023 Reanalysis data and numerical model are employed to uncover the mechanisms of spring (March–April) Arctic surface warming. Different from other seasons, little additional solar radiation absorption or seasonal heat storage release contributes to Arctic ...
Haijin Dai
doaj +1 more source
Potential for an Arctic‐breeding migratory bird to adjust spring migration phenology to Arctic amplification [PDF]
Global Change Biology, 2017 AbstractArctic amplification, the accelerated climate warming in the polar regions, is causing a more rapid advancement of the onset of spring in the Arctic than in temperate regions. Consequently, the arrival of many migratory birds in the Arctic is thought to become increasingly mismatched with the onset of local spring, consequently reducing ...
Thomas K. Lameris +5 more
openaire +5 more sources
FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source
Arctic dimension of global warming
Лëд и снег, 2015 A brief assessment of the global warming in the Arctic climate system with the emphasis on sea ice is presented. The Arctic region is coupled to the global climate system by the atmosphere and ocean circulation that providesa major contribution to the ...
G. V. Alekseev
doaj +1 more source
Polar Amplification: Stronger Warming in the Arctic and Antarctic
Frontiers for Young Minds, 2022 During the past several decades, our planet has warmed because people have added a lot of greenhouse gases to the atmosphere. The warming in the polar regions (the Arctic, and parts of the Antarctic) has been much higher than in the rest of the world.
Irina Gorodetskaya +2 more
openaire +1 more source