Results 61 to 70 of about 800,031 (390)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
The Arctic vector of Switzerland [PDF]
Научно-аналитический вестник Института Европы РАН, 2019 In connection with Switzerland’s official observer status in the Arctic Council that was gained in 2017, the article deals with the Swiss contribution to the Arctic and Antarctic study, as well as issues of cooperation with Russia in the Arctic ...
Valery Zhuravel
doaj +1 more source
Member States as ‘Trustees’ of the Union? The European Union and the Arctic Council. EU Diplomacy Paper 12 / 2017 [PDF]
, 2017 This paper sets out to analyse two elements often overlooked in the literature on the European Union (EU) and international organisations, namely EU representation in the Arctic Council and the duty of sincere cooperation as a tool of EU representation ...
Bjerkem, Johan
core
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
The effectiveness of the Arctic Council [PDF]
Polar Research, 2012 Created in 1996, the Arctic Council has now been in operation long enough to justify a systematic effort to assess its effectiveness. To explore this topic, we created a questionnaire and circulated it to a large number of individuals who have ...
Paula Kankaanpää +1 more
doaj +1 more source
PICES Press, Vol. 7, No. 2, July 1999 [PDF]
, 1999 Improving PICES CO2 measurement quality The status of the Bering Sea: July - December 1998 The state of the eastern North Pacific since October 1998 The state of the western North Pacific in the second half of 1998 Paul Henry LeBlond Report on ...
core
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Arctic, 2019 This article investigates differences in circumpolar indigeneities in three major Arctic nations: Russia, Canada, and the United States (Alaska). Russia has different ways of recognizing indigeneity in law, and that definition of indigeneity excludes ...
E. Sidorova
semanticscholar +1 more source
Assessing Devolution in the Canadian North: A Case Study of the Yukon Territory [PDF]
, 2012 Despite a rich literature on the political and constitutional development of the Canadian territorial North, few scholars have examined the post-devolution environment in Yukon.
Alcantara, Christopher +2 more
core +5 more sources