Results 41 to 50 of about 1,963,224 (195)
Arctic interests and policy of France [PDF]
Арктика и Север, 2016 The author considers scientific, economic and political activities of France for the development and exploration of the Arctic, providing security there.
Yuri I. Rubinsky
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
The Protection of Arctic Environment (International legal aspect)
RUDN Journal of Law, 2008 The article deals with international legal rules focusing on the protection of the Arctic environment, regulation of the activity of the Arctic states in the Arctic by international and national rules, also such international organization as Arctic ...
S N Tchistukhina
doaj
Arktisk Råd – et mellemfolkeligt samarbejde
Internasjonal PolitikkForud for Arktisk Råds tilblivelse i 1996 foregik der et omfattende arbejde mellem staterne, og ikke mindst af de arktiske oprindelige folk. Inuit Circumpolar Council (ICC), som repræsenterer Inuit i Kalaallit Nunaat (Grønland), Canada, Alaska og ...
Sara Olsvig
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The Arctic vector of Switzerland [PDF]
Научно-аналитический вестник Института Европы РАН, 2019 In connection with Switzerland’s official observer status in the Arctic Council that was gained in 2017, the article deals with the Swiss contribution to the Arctic and Antarctic study, as well as issues of cooperation with Russia in the Arctic ...
Valery Zhuravel
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Senior Arctic Official (SAO) Report to Ministers, Tromsø Norway, 2009 [PDF]
, 2009 Arctic Council Senior Arctic Officials' (SAO) Report to Ministers.
Arctic Council, -
core +1 more source
The effectiveness of the Arctic Council [PDF]
Polar Research, 2012 Created in 1996, the Arctic Council has now been in operation long enough to justify a systematic effort to assess its effectiveness. To explore this topic, we created a questionnaire and circulated it to a large number of individuals who have ...
Paula Kankaanpää +1 more
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