Results 51 to 60 of about 147,760 (311)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
The effectiveness of the Arctic Council [PDF]
Polar Research, 2012 Created in 1996, the Arctic Council has now been in operation long enough to justify a systematic effort to assess its effectiveness. To explore this topic, we created a questionnaire and circulated it to a large number of individuals who have ...
Paula Kankaanpää +1 more
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Arktisk Råd – et mellemfolkeligt samarbejde
Internasjonal PolitikkForud for Arktisk Råds tilblivelse i 1996 foregik der et omfattende arbejde mellem staterne, og ikke mindst af de arktiske oprindelige folk. Inuit Circumpolar Council (ICC), som repræsenterer Inuit i Kalaallit Nunaat (Grønland), Canada, Alaska og ...
Sara Olsvig
doaj +1 more source
PICES Press, Vol. 7, No. 2, July 1999 [PDF]
, 1999 Improving PICES CO2 measurement quality The status of the Bering Sea: July - December 1998 The state of the eastern North Pacific since October 1998 The state of the western North Pacific in the second half of 1998 Paul Henry LeBlond Report on ...
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Har Arktisk råd noen betydning?
Internasjonal PolitikkArtikkelen er en personlig vurdering av betydningen til Arktisk råd etter å ha vært såkalt SAO Chair i to år. Abstract in English Does the Arctic Council Matter?
Morten Høglund
doaj +1 more source
United Caribou Association of the Nunamiut [PDF]
, 2016 Presented to the Faculty Of the University of Alaska Anchorage In Partial Fulfillment of the Requirements for the Degree of MASTER OF PUBLIC HEALTHCaribou is one food source that the people in Anaktuvuk Pass, Alaska rely on as a dependable and ...
Tooyak, Andrew Jr
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FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Polar Oceans in Peril and a Planet at Risk [PDF]
, 2009 The snow-covered lands and icy waters of these polar regions are, for many people, the purest examples of true wilderness left on this planet. While the Arctic has been home to indigenous peoples for millennia, Antarctica has only played host to visiting
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