Results 71 to 80 of about 800,031 (390)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
The Arctic Council and health issues [PDF]
International Journal of Circumpolar Health, 2002 The Arctic Council has been recognized as a unique forum for co-operation between national governments and indigenous peoples in the Arctic. The Council was established in 1996 by the eight Arctic countries with outreach above the Arctic Circle; Canada, Denmark (including Greenland and the Faroe Islands), Finland, Iceland, Norway, the Russian ...
openaire +3 more sources
Sustainable Development, Natural Resource Extraction, and the Arctic: The Road Ahead [PDF]
, 2016 Sustainable development has emerged as an integral nexus, linking together critically important global issues including environmental stewardship and economic growth. Understanding sustainable development demands a close analysis of evolving definitions,
Canuel, Edward
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
The Protection of Arctic Environment (International legal aspect)
RUDN Journal of Law, 2008 The article deals with international legal rules focusing on the protection of the Arctic environment, regulation of the activity of the Arctic states in the Arctic by international and national rules, also such international organization as Arctic ...
S N Tchistukhina
doaj
Revista Brasileira de Política Internacional, 2023 The effects of climate change over the Arctic region have attracted manifold interests in the last decades from several state and non-state actors. Due to a flawed institutional capacity to promote a multi-stakeholder approach in Arctic affairs, the main
GAO Fei +2 more
doaj +1 more source
Preparing for a Northwest Passage: A Workshop on the Role of New England in Navigating the New Arctic [PDF]
, 2018 Preparing for a Northwest Passage: A Workshop on the Role of New England in Navigating the New Arctic (March 25 - 27, 2018 -- The University of New Hampshire) paired two of NSF\u27s 10 Big Ideas: Navigating the New Arctic and Growing Convergence ...
Ashcraft, Catherine M +13 more
core +1 more source
, 2020 You broke the law. There should be a law. Loi du 29 juillet 1881 sur la liberte de la presse. It is the law of God. It is the law of our ancestors. It is a law of nature. It is the second law of thermodynamics. It is the tax code. What is law?
Levinson, Bruce
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Arktisk Råd – et mellemfolkeligt samarbejde
Internasjonal PolitikkForud for Arktisk Råds tilblivelse i 1996 foregik der et omfattende arbejde mellem staterne, og ikke mindst af de arktiske oprindelige folk. Inuit Circumpolar Council (ICC), som repræsenterer Inuit i Kalaallit Nunaat (Grønland), Canada, Alaska og ...
Sara Olsvig
doaj +1 more source