Results 61 to 70 of about 2,216,394 (334)

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

open access: yesFEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt   +4 more
wiley   +1 more source

Occasional Publications on Northern Life, No. 04 [PDF]

open access: yes, 1983
The need to exchange information on research in reindeer and caribou diseases became apparent to investigators attending the Second International Reindeer/Caribou Symposium in Roros, Norway, in 1979.
Dieterich, Robert A., Morton, Jamie K.
core  

Respect for Grizzly Bears: An Aboriginal Approach for Co-existence and Resilience [PDF]

open access: yes, 2009
Aboriginal peoples’ respect for grizzly bear (Ursus arctos) is widely acknowledged, but rarely explored, in wildlife management discourse in northern Canada.
Clarke, Douglas A., Slocombe, D. Scott
core   +3 more sources

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

open access: yesFEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt   +8 more
wiley   +1 more source

Overall lifestyle changes in adulthood are associated with cancer incidence in the Norwegian Women and Cancer Study (NOWAC) – a prospective cohort study

open access: yesBMC Public Health, 2023
Background Cancer is a leading cause of premature death worldwide and incidence is expected to rise in the coming decades. Many cohort studies, measuring lifestyle factors at one time-point, have observed that overall healthy lifestyles were inversely ...
Sairah L. F. Chen   +6 more
doaj   +1 more source

An investigation into the effect on skin surface temperature of three cryotherapy modalities [PDF]

open access: yes, 2009
OBJECTIVE: To investigate the comparative cooling effect at the knee, of Crushed Ice and two commonly used commercial cryotherapy modalities, following a clinically relevant application of 20 minutes.
Hardaker, Natalie   +3 more
core  

Hexabromocyclododecane and hexachlorocyclohexane: How lessons learnt have led to improved regulation [PDF]

open access: yes, 2014
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2014 Taylor & Francis.The use of chemicals by society has many benefits but contamination of the environment is an unintended consequence.
BSEF   +14 more
core   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

open access: yesMolecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak   +14 more
wiley   +1 more source

Social-ecological soundscapes: examining aircraft-harvester-caribou conflict in Arctic Alaska [PDF]

open access: yes, 2017
Thesis (M.S.) University of Alaska Fairbanks, 2017As human development expands across the Arctic, it is crucial to carefully assess the impacts to remote natural ecosystems and to indigenous communities that rely on wild resources for nutritional and ...
Stinchcomb, Taylor R.
core  

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

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