Results 41 to 50 of about 33,196 (315)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Innovation Potential of the Arctic Regions of Russia
Арктика и Север, 2022 The paper provides a comparative analysis of foreign and Russian methodologies for assessing innovation potential. It is shown that foreign methodologies cannot be used to determine the innovation potential of the Arctic regions of Russia due to specific
Vyacheslav A. Tsukerman +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Masters Students' Perceptions of Distance and Transport Options
Education in the North, 2018 This article is situated within the Arctic Regions North Norway and North/East Iceland. It presents a study on what motivates adults in Arctic regions to apply for and complete a Master’s degree in Education.
Mirjam Harkestad Olsen +1 more
doaj +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
THE ECOLOGICAL PROBLEMS OF THE RUSSIAN FEDERATION ARCTIC
Известия высших учебных заведений: Нефть и газ, 2015 The results of ecological researches in the Arctic zone of the Russian Federation (Purovski district of Yamal-Nenets Autonomous okrug) are presented.
N. L. Mamaeva, S. A. Petrov
doaj +1 more source
Sound absorption in Arctic regions [PDF]
The Journal of the Acoustical Society of America, 1987 Sound absorption in seawater involves relaxations of magnesium sulfate, boric acid, and magnesium carbonate. Absorption varies with both region and depth, due mainly to the pH dependence of the boric acid relaxation. The nominal seawater pH range is 7.7–8.3 and magnitudes can vary over nearly a factor of 4 at low frequencies.
R. H. Mellen +2 more
openaire +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Comparing Arctic Regional Climate Model [PDF]
Eos, Transactions American Geophysical Union, 2002 Recent climate modeling results show the Arctic to be a region of particular importance and vulnerability to global climate change. Despite the climatic significance of the Arctic, many physical processes occurring in this region are still not well understood.
J. A. Curry, A. H. Lynch
openaire +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source