Results 51 to 60 of about 43,657 (340)

Adhesion‐Related Macrophages Regulate Metabolic Homeostasis Through CAV‐1 Dependency

Advanced Science, EarlyView.
Adipose tissue harbors a distinct macrophage subpopulation, termed adhesion‐related macrophages (ARMs), which stably adhere to adipocytes. In obesity, ARMs represent the major expanding macrophage subset. They acquire material from adipocytes and rely on Caveolin‐1 for sustained lipid handling.
Wanyu Hu, Xiyan Liao, Limin Xie, Xiaoxiao Sun, Luodi Jing, Qin Zeng, Hongwei Jiang, Haowei Zhang, Lei Li, Fanqi Wang, Dandan Wang, Ying Mei, Yujin Din, Jianfeng Song, Wufuer Aini, Hui Zhou, Wanqin Xie, Helong Dai, Wei Liu, Joey Liu, Yan Cheng, Feng Liu, Willa A. Hsueh, Tuo Deng   +23 more
wiley   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Cost–Benefit Analysis of a Trans-Arctic Alternative Route to the Suez Canal: A Method Based on High-Fidelity Ship Performance, Weather, and Ice Forecast Models

Journal of Marine Science and Engineering, 2023
Climate change in recent years has produced viable shipping routes in the Arctic. However, critical uncertainties related to maritime operations in the Arctic make it difficult to predict ship speeds in ice and, thus, the voyage time and fuel costs. Cost–
Zhiyuan Li, Li Ding, Luofeng Huang, Jonas W. Ringsberg, Hui Gong, Nicolas Fournier, Zhenju Chuang   +6 more
doaj   +1 more source

Arctic Vessel Traffic in the Bering Strait [PDF]

, 2014
This brief examines the risks posed by increasing vessel traffic and outlines a series of mitigation measures that authorities can implement to protect all those who depend on the Bering Strait—wildlife and indigenous communities, as well as ships and ...

core  

Trained Memory of Uterine Macrophages Improves Subsequent Pregnancy Outcomes

Advanced Science, EarlyView.
This study identifies that pregnancy imprints a durable, pregnancy‐specific form of trained immune memory in uterine macrophages, marked by the emergence of LILRB3+/PIR‐B+ cells that expand across gestations, acquire a tolerogenic and metabolically rewired phenotype, and actively protect against inflammatory pregnancy loss in mice.
Jing Wang, Ning Lu, Xin‐Xiu Lin, Xu‐Hui Fang, Yi‐Hui Li, Qing‐Peng Luo, Yu‐Ting Peng, Gil Mor, Ai‐Hua Liao   +8 more
wiley   +1 more source

Projected changes to Arctic shipping routes after stratospheric aerosol deployment in the ARISE-SAI scenarios

Frontiers in Climate
IntroductionRapid reductions in Arctic sea ice in response to warming have led to increased interest in using the Arctic Ocean for commercial shipping. As the world warms, however, different strategies are being considered to stabilize or reduce surface ...
Ariel L. Morrison, Debanjali Pathak, Elizabeth A. Barnes, James W. Hurrell   +3 more
doaj   +1 more source

Unpacking Canada’s Arctic Shipping Safety, Security, and Defence Functions [PDF]

, 2023
Andrea Charron, David Snider
openalex   +1 more source

Assessments in Policy-Making: Case Studies from the Arctic Council [PDF]

, 2014
Julkaistu ...
Banul, Karolina, Kankaanpää, Paula, Koivurova, Timo, Lesser, Pamela, Stępień, Adam, Śmieszek, Małgorzata   +5 more
core  

Decoding the Mechanism of Action of a Parasite TGFβ Antagonist Inspires the Creation of Cell‐Type‐Specific TGFβ Modulators

Advanced Science, EarlyView.
The mammalian TGFβ interacts with ubiquitously expressed TGFBR1 and TGFBR2, and current TGFβ‐targeting agents are non‐cell‐selective. The cooperative interaction of the modular parasite TGFβ antagonist with multiple host (co‐)receptors empowers the design of TGM chimeras and bispecific antibodies that activate or inhibit TGFβ signaling in a cell ...
Maarten van Dinther, Tristin Schwartze, Jiying Zhang, Kun Fan, Gerard van der Zon, Luke Power, Cynthia S. Hinck, Claire Ciancia, Ananya Mukundan, Roman Gonzalez‐Prieto, Peter van Veelen, Rick M. Maizels, Andrew P. Hinck, Peter ten Dijke   +13 more
wiley   +1 more source

Evolutionary game analysis of Arctic shipping black carbon emission reduction strategies based on government regulation and port fee differential policies

Humanities & Social Sciences Communications
The issue of black carbon (BC) emissions from Arctic shipping has garnered significant attention from the international community. Promoting action among key stakeholders is particularly critical at this juncture.
Xinli Qi, Zhenfu Li, Yiran Zhang, Qiqi Zhang, Chunrui Song   +4 more
doaj   +1 more source