Results 81 to 90 of about 276,492 (307)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Use of foreign mixtures of lawn grasses in greening of roadside areas in central Yakutia [PDF]
BIO Web of ConferencesCurrently, in Yakutia, the construction of apartment buildings is rapidly developing, new neighborhoods are being created, roads, squares, etc. are being repaired, and this requires work on landscaping (sowing lawns, planting trees, shrubs and shrubs ...
Ustinova V.V. +3 more
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Ethnic identity and aspirations among rural Alaska youth [PDF]
, 1998 The villages of rural Alaska comprise one of the most exceptional, yet least visible, sociocultural environments in the United States They are geographically remote, and set off from the mainstream also by their unique Eskimo, Indian or Aleut cultures ...
Duncan, Cynthia M. +3 more
core +2 more sources
Водное хозяйство России: проблемы, технологии, управление, 2019 Surface water bodies are most vulnerable to chemical pollution. Objective: to study the hydro/chemical indicators of the state of surface waters of the Yamalo-NenetskAutonomous District and to assess their quality.
Yelena V. Agbalyan +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
The reversibility of sea ice loss in a state-of-the-art climate model [PDF]
, 2011 Rapid Arctic sea ice retreat has fueled speculation about the possibility of threshold (or ‘tipping point’) behavior and irreversible loss of the sea ice cover. We test sea ice reversibility within a state-of-the-art atmosphere–ocean global climate model
Armour, K. C. +4 more
core
Ozone depletion events observed in the high latitude surface layer during the TOPSE aircraft program [PDF]
, 2003 During the Tropospheric Ozone Production about the Spring Equinox (TOPSE) aircraft program, ozone depletion events (ODEs) in the high latitude surface layer were investigated using lidar and in situ instruments.
Atlas, EL +31 more
core +1 more source
Rethinking the heuristic traps paradigm in avalanche education: Past, present and future
Cogent Social Sciences, 2020 This paper will review the emergence and adoption of decision heuristics as a conceptual framework within the avalanche research and education community and demonstrate how this emphasis on the heuristic decision framework has anchored and was critical ...
Jerry Johnson +4 more
doaj +1 more source