Results 111 to 120 of about 24,202 (294)
Nature Communications, 2018 Before the onset of puberty, Polycomb proteins repress the expression of Kiss1 in KNDy neurons of the arcuate nucleus. Here, by CRISPR-Cas9-directed epigenome editing and RNAi, the authors show that coordinated action of Mll proteins at the Kiss1 ...
Carlos A. Toro +4 more
doaj +1 more source
CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction
Advanced Science, EarlyView.CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma +12 more
wiley +1 more source
Multi‐Axis Stretchable Zippers for Personalized Wound Healing
Advanced Science, EarlyView.Multi‐axis stretchable zippers can adapt to complex wound morphologies and enable personalized wound treatment through programmable contraction. This morphological matching strategy helps accelerate wound closure, improve blood perfusion, promote epithelial regeneration, and enhance collagen remodeling, pioneering new directions for personalized and ...
Siyuan Cai +16 more
wiley +1 more source
Advanced Science, EarlyView.A senolytic sonovaccine platform (SenoVac) is developed, in which senescent cell‐derived vesicles serve as broad senescent cell antigen reservior. The “2‐step” click chemistry strategy for effective lymph node delivery, and ultrasound‐triggered endosomal escape to boost cross‐presentation, ensures efficient senescent cell clearance and disease ...
Liang Zhang +10 more
wiley +1 more source
Steroid hormone regulation of neurons in the hypothalamic arcuate nucleus
, 1998 Menopause is accompanied by neuronal hypertrophy and increased neurokinin B (NKB) gene expression in the human infundibular (arcuate) nucleus. We have hypothesized that these changes are secondary to withdrawal of gonadal steroids.
Danzer, Steven Craig, 1970-
core
Changes in NPY staining in the arcuate nucleus during and after food restriction in lactating rats [PDF]
, 1996 This study investigated the effects of food restriction on Neuropeptide Y (NPY) staining in the arcuate nucleus of lactating rats to evaluate a role for NPY in the maintenance of lactational diestrus in food restricted rats.
Abizaid, Alfonso
core
Association between pulmonary hypoplasia and hypoplasia of arcuate nucleus in stillbirth
, 2003 OBJECTIVE: To investigate lung development and to correlate pulmonary hypoplasia with hypoplasia of the arcuate nucleus in stillbirths. STUDY DESIGN: We examined 26 stillbirths which occurred after 25 complete gestational weeks.
L. Matturri +6 more
core +1 more source
PlantGFM: A Genomic Foundation Model for Discovery and Creation of Plant Genes
Advanced Science, EarlyView.A plant genomic foundation model pre‐trained on 12 species enables both accurate gene prediction and de novo gene design. Through AI‐human knowledge screening, seven designed sequences showed transcriptional activity in plants, with two expressing stable proteins—demonstrating the first DNA‐RNA‐protein expression of LLM‐generated genes in plants and ...
Changhao Li +10 more
wiley +1 more source
, 2015 A. Immunostaining of LC3 (green) in the arcuate hypothalamic nucleus of lean and obese mice (8 weeks of a HFD). B. Immunostaining of LC3 (green) in the arcuate hypothalamic nucleus of lean and obese mice (16 weeks of a HFD).
Andressa Coope (373558) +10 more
core +1 more source
Advanced Science, EarlyView.The biomimetic self‐assembly nanomedicine reversing atherosclerosis via senotherapy strategy. ABSTRACT The greatest challenge in atherosclerosis (AS) management lies in achieving lesion reversal, not merely slowing progression. Senescent cell accumulation—driven by continuous generation and apoptotic resistance—perpetuates plaque pathology and ...
Yuhan Tian +9 more
wiley +1 more source