Results 201 to 210 of about 117,203 (308)

Improving retrospective ARDS case-finding using a simple 72-h physiologic persistence rule. [PDF]

Intensive Care Med Exp
Marshall DC, Patel BV, Gordon AC, Antcliffe DB, Parbhoo S, Komorowski M.   +5 more
europepmc   +1 more source

Smart Integration of Structural Biology and Medicinal Chemistry to Unlock Target‐Driven Drug Discovery

Medicinal Research Reviews, Volume 46, Issue 4, Page 921-944, July 2026.
ABSTRACT To enhance drug discovery efforts, medicinal chemists should evaluate, filter, and utilize relevant structural information about target proteins. Acquiring and interpreting protein structures is crucial for elucidating ligand‐receptor interactions and addressing ADME‐related considerations, making it an essential aspect of medicinal chemistry.
Matteo Rossi Sebastiano, Giulia Apprato, Serena Francisco, Giuseppe Ermondi, Giulia Caron   +4 more
wiley   +1 more source

Epidemiology of the acute respiratory distress syndrome and the prognostic validity of SpO₂:FiO₂ under the expanded Global definition. [PDF]

Crit Care
Bennett RM, Housel KC, Jones TK, Miano TA, Emre G, Turner A, Esperanza M, Erlich M, Ittner C, Shashaty MGS, Meyer NJ, Anderson MR, Christie JD, Reilly JP.   +13 more
europepmc   +1 more source

Offline Reconstruction of Diffusion MRI Acquisitions for Comparison Between Complex PCA‐Based and AI‐Based Denoising

Magnetic Resonance in Medicine, Volume 96, Issue 1, Page 435-447, July 2026.
ABSTRACT Purpose Optimal diffusion MRI (dMRI) data for image denoising is often unavailable from scanner reconstruction. In this work, we make available an offline reconstruction pipeline for GE dMRI acquisitions, giving access to complex dMRI data. Furthermore, we compare the efficacy of GE HealthCare's AIR‐Recon DL (ARDL), a proprietary convolutional
Francesco D'Antonio, Shaun Warrington, Jose‐Pedro Manzano‐Patron, Paul S. Morgan, Stamatios N. Sotiropoulos   +4 more
wiley   +1 more source

NLRP3 inflammasomes at the ARDS-cancer interface: mechanisms and translational hypotheses. [PDF]

Front Immunol
Shebbo S, Mahmoud DE, Alateyah N, Hosseini SH, Al-Haidose A, Ramirez SA, Zeidan A, Abdallah AM.   +7 more
europepmc   +1 more source

Endoplasmic reticulum stress and the unfolded protein response in lung diseases: molecular pathways and therapeutic interventions

The Journal of Pathology, Volume 269, Issue 3, Page 268-283, July 2026.
Abstract Endoplasmic reticulum stress (ERS) occurs when the protein‐folding capacity of the endoplasmic reticulum (ER) is overwhelmed, triggering the unfolded protein response (UPR) to restore homeostasis. However, severe or persistent ERS can shift the UPR toward pro‐inflammatory, apoptotic, and fibrotic signaling, thereby exacerbating tissue injury ...
Lanlan Song, Yichen Liu, Chen Xu, Yaochen Zhang, Kaiming Xu, Dan Yao, Xiaoying Huang   +6 more
wiley   +1 more source

Neutrophil-to-Lymphocyte Ratio, Systemic Immune-Inflammation Index, and HALP Score as Predictors of Mortality in Acute Respiratory Distress Syndrome. [PDF]

J Clin Med
Sayed AA, Alrehaili LA, Alsuhaymi AO, Alnuzha EH, Alsaedi GT, Alsharif RM, Alsaedi SH, Althubyani SS, Alahmadi TA, Alharbi WF.   +9 more
europepmc   +1 more source

Co‐occurring opioid and stimulant use disorder and the relationship to severe maternal morbidity

Pregnancy, Volume 2, Issue 4, July 2026.
Abstract Introduction To evaluate the impact of the use of opioids, stimulants, or both on the rates of various severe maternal morbidity (SMM) events during inpatient delivery‐related hospitalizations among patients with substance use disorder (SUD).
Tucker E. Doiron, Noor Al‐Hammadi, Alexandra R. Schroeder, Niraj R. Chavan   +3 more
wiley   +1 more source

Heterogeneous Causes of Acute Respiratory Distress Syndrome Correlate With Distinct Peripheral Polyunsaturated Fatty Acid Metabolites. [PDF]

FASEB J
Leuenberger LA, Bednash JS, Schott E, Mikacenic C, Morrell ED, Richardson C, Fussner LA, Horowitz JC, Mallampalli RK, Shaikh SR, Tighe RM, Gowdy KM.   +11 more
europepmc   +1 more source