ABSTRACT Aims To evaluate the associations between semaglutide initiation and long‐term skeletal outcomes in people with obesity, stratified by type 2 diabetes (T2D) status, using target trial emulation. Materials and Methods This retrospective cohort study used the TriNetX federated electronic health record network.
Yu‐Nan Huang +8 more
wiley +1 more source
Stress-hyperglycemia ratio and glycemic variability predict severity and mortality in sepsis-associated acute respiratory distress syndrome. [PDF]
Chen H +14 more
europepmc +1 more source
Inflammatory Stewardship—A Perspective for Active Management of Acute Inflammation
Inflammatory stewardship frames inflammation as a manageable clinical domain requiring explicit strategy, governance, and feedback. It aligns diagnostics, risk stratification, biomarker interpretation, and immunomodulatory decisions across perioperative and critical‐care teams.
Lennart Finn Herrlich +2 more
wiley +1 more source
Severe acute respiratory distress syndrome associated with human metapneumovirus infection in a morbidly obese adult. [PDF]
Sugai N, Iwanaga W.
europepmc +1 more source
miniMORPH: A Morphometry Pipeline for Low‐Field MRI in Infants
miniMORPH is a fully automated pipeline for extracting regional brain volumes from ultra‐low‐field (0.064 T) infant MRI without super‐resolution. Benchmarking against high‐field references shows it preserves between‐subject variation and yields face‐valid developmental and birthweight‐related effects, enabling scalable neurodevelopmental morphometry ...
Chiara Casella +18 more
wiley +1 more source
Morphological subphenotypes in acute pancreatitis-related ARDS: limitations, extensions, and research priorities. [PDF]
Pensier J, De Jong A, Jaber S.
europepmc +1 more source
Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu +4 more
wiley +1 more source
Prognostic nutritional index, Naples prognostic score and Osaka prognostic score as predictors of acute respiratory distress syndrome in non-diabetes mellitus patients with sepsis: a loss of predictive efficacy of NPS and OPS in diabetes mellitus cohorts. [PDF]
Wu J, Qiu W, Lin X, Wu J, Li R.
europepmc +1 more source
This study presents HAEP@Res sub‐microgels as a lung‐targeted delivery system integrating antioxidant activity with anti‐inflammatory therapy. The sub‐microgels demonstrate excellent biocompatibility, efficiently scavenge intracellular ROS, and downregulate pro‐inflammatory cytokines and genes in a Bleo‐induced ALI mouse model. These findings highlight
Bo Liu +10 more
wiley +1 more source

