Results 231 to 240 of about 99,561 (320)

Myeloid‐Driven Immune Suppression Subverts Neutralizing Antibodies and T Cell Immunity in Severe COVID‐19

Journal of Medical Virology, Volume 97, Issue 4, April 2025.
ABSTRACT The objective of this study was to better understand immune failure mechanisms during severe acute respiratory syndrome coronavirus 2, SARS‐CoV‐2 infection, which are critical for developing targeted vaccines and effective treatments. We collected 34 cases representing different disease severities and performed high‐quality single‐cell TCR/BCR
Cong Lai, Su Lu, Yilin Yang, Xiaoyu You, Feixiang Xu, Xinran Deng, Lulu Lan, Yuesheng Guo, Zhongshu Kuang, Yue Luo, Li Yuan, Lu Meng, Xueling Wu, Zhenju Song, Ning Jiang   +14 more
wiley   +1 more source

Effect of Neutrophil Elastase Inhibitor (Sivelestat Sodium) on Oxygenation in Patients with Sepsis-Induced Acute Respiratory Distress Syndrome. [PDF]

J Inflamm Res
Wu T, Wang T, Jiang J, Tang Y, Zhang L, Jiang Z, Liu F, Kong G, Zhou T, Liu R, Guo H, Xiao J, Sun W, Li Y, Zhu Y, Liu Q, Xie W, Qu Y, Wang X.   +18 more
europepmc   +1 more source

Low Molecular Weight Heparin Dosing in Relation to Postoperative Bleeding After Tracheotomy in Patients Infected With SARS‐CoV‐2—A Descriptive Study

Laryngoscope Investigative Otolaryngology, Volume 10, Issue 2, April 2025.
Prevalence of bleeding as a complication to surgical tracheotomy was analyzed retrospectively in relation to dosing of LMWH in patients infected with SARS‐CoV‐2. Decreased dose of LMWH on the day of surgery was not associated with a risk reduction for post‐surgical bleeding in patients with SARS‐CoV‐2 who received tracheotomy. Increasing age was a risk
David Victorin, Henrik Bergquist, Louise Hafsten, Åsa Nihlén, Ellen Lindell   +4 more
wiley   +1 more source

Clinical Performance of Spo2/Fio2 and Pao2/Fio2 Ratio in Mechanically Ventilated Acute Respiratory Distress Syndrome Patients: A Retrospective Study. [PDF]

Crit Care Med
Coppola S, Pozzi T, Catozzi G, Monte A, Frascati E, Chiumello D.   +5 more
europepmc   +1 more source

The Peptide PROTAC Modality: A New Strategy for Drug Discovery

MedComm, Volume 6, Issue 4, April 2025.
Peptide PROTAC is a bifunctional molecule generally composed of a target protein binding peptide (TBP), a linker peptide (LP), an E3 ligase binding peptide (EBP), and a delivery‐enhancing peptide (DEP), which can bind to the target protein (P) and E3 ligase (E3), inducing P to be labeled with ubiquitin (Ub) and subsequently recognized and degraded by ...
Youmin Zhu, Yu Dai, Yuncai Tian
wiley   +1 more source

Dexmedetomidine administration is associated with reduced mortality in patients with sepsis-induced acute respiratory distress syndrome: a retrospective study. [PDF]

BMC Anesthesiol
Zhang J, Jia Z, Zhang Y, Tao Z.
europepmc   +1 more source

Prevalence Trends and Patterns of Perinatal ADHD Stimulant Medication Use in British Columbia, Canada

Pharmacoepidemiology and Drug Safety, Volume 34, Issue 4, April 2025.
ABSTRACT Purpose Given the increase in attention‐deficit/hyperactivity disorder (ADHD) diagnoses and stimulant medication use among female adults, this study describes the prevalence trends of perinatal ADHD stimulant medication use in British Columbia, Canada, along with characteristics and patterns of use.
Amanda Nitschke, Ali Salmanpour, Paramdeep Kaur, Helena Abreu do Valle, Chelsea Elwood, Anne Gadermann, Martin Guhn, Catriona Hippman, Angie Ip, Jalisa L. Karim, Tim F. Oberlander, Peter M. Socha, Gillian E. Hanley   +12 more
wiley   +1 more source

Evaluating the Use of Inhaled Budesonide and Ipratropium Bromide Combination in Patients at High Risk of Acute Respiratory Distress Syndrome Development: A Randomized Controlled Trial. [PDF]

Pharmaceuticals (Basel)
Moustafa HAM, Elbery FH, Al Meslamani AZ, Okda SM, Alsfouk BA, Kassem AB.   +5 more
europepmc   +1 more source

Proteoglycans and Hyaluronan in Normal and Aberrant Lung Development

Proteoglycan Research, Volume 3, Issue 2, April 2025.
ABSTRACT Lung development is a tightly regulated process that progresses through five distinct stages: embryonic, pseudoglandular, canalicular, saccular, and alveolar. Each stage is characterized by coordinated cellular interactions and structural changes driven by signals from epithelial, endothelial, and mesenchymal cells.
Andrea Reszegi, Gabor Petovari, Nikitha Damisetty, Stavros Garantziotis, Rashmin C. Savani   +4 more
wiley   +1 more source

Dynamic Immune Indicator Changes as Predictors of ARDS in ICU Patients with Sepsis: A Retrospective Study. [PDF]

Int J Gen Med
Lu X, Chen Y, Zhang G, Zeng X, Lai L, Qu C.   +5 more
europepmc   +1 more source