Results 51 to 60 of about 117,203 (308)

Metabolic signatures of ARDS and ARDS heterogeneity [PDF]

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2021
Lucile Neyton, Carolyn S. Calfee
openaire   +2 more sources

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

Advanced Science, EarlyView.
In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin, Xinran Deng, Haonan Wang, Yamei Jiang, Jian Sun, Hailin Ding, Ming Ye, Xiaoting Wang, Yu Wang, Li Yuan, Zhenju Song, Xinhua Lin, Shenfei Sun, Ning Jiang   +13 more
wiley   +1 more source

‘The Contrast May Burn a Little' - Case Report of Severe, Anaphylactic Shock Following MRI IV Contrast

Saudi Journal of Emergency Medicine
We present a case of a 46-year-old male who developed acute onset shortness of breath, hypotension, and hypoxia soon after receiving IV contrast for a routine MRI scan.
Elrasheed Salih, Mohammed Anzal Rehman, Rishi Prasad   +2 more
doaj   +1 more source

Simvastatin to reduce pulmonary dysfunction in patients with acute respiratory distress syndrome: the HARP-2 RCT

Efficacy and Mechanism Evaluation, 2018
Background: Acute lung injury is a common devastating clinical syndrome characterised by life-threatening respiratory failure requiring mechanical ventilation and multiple organ failure, and is a major cause of morbidity and mortality.
Daniel F McAuley, John G Laffey, Cecilia M O’Kane, Gavin D Perkins, Brian Mullan, Thomas J Trinder, Paul Johnston, Phillip A Hopkins, Andrew J Johnston, Lynn Murphy, Christine McNally, Ashley M Agus, Clíona McDowell, Colette Jackson   +13 more
doaj   +1 more source

Comparing lung mechanics of patients with COVID related respiratory distress syndrome versus non-COVID acute respiratory distress syndrome: a retrospective observational study

Journal of Mechanical Ventilation, 2022
Background Most patients admitted to the intensive care unit with coronavirus disease (COVID-19) develop severe respiratory failure. Understanding lung mechanics helps to guide protective mechanical ventilation, improve oxygenation, and reduce the ...
Francisco Chacón-Lozsán, Péter Tamási   +1 more
doaj   +1 more source

Überleben und Langzeitoutcome von Patienten mit schwerem ARDS und iLA-Therapie

, 2009
Diese Arbeit untersucht das Überleben von 136 Patienten die zwischen 1996 und 2007 mit schwerem ARDS die zwischen 1996 und 2007 mit einem interventional lung-assistant (iLA) am Universitätsklinikum Regensburg behandelt wurden.
Schuster, Philipp
core   +1 more source

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

ML Workflows for Screening Degradation‐Relevant Properties of Forever Chemicals

Advanced Science, EarlyView.
The environmental persistence of per‐ and polyfluoroalkyl substances (PFAS) necessitates efficient remediation strategies. This study presents physics‐informed machine learning workflows that accurately predict critical degradation properties, including bond dissociation energies and polarizability.
Pranoy Ray, Andrew R. Castillo, Manoj Kolel‐Veetil, Surya R. Kalidindi   +3 more
wiley   +1 more source

Leveraging Administrative Health Data to Capture Rare Adverse Drug Reactions: Identifying Pediatric Patients With Trimethoprim-Sulfamethoxazole Acute Respiratory Distress Syndrome. [PDF]

Pharmacol Res Perspect
ABSTRACT Rare adverse drug reactions (ADRs) are underrecognized and underreported in the electronic medical record (EMR). These events often require clinical review, making systematic identification challenging. The study aim was to develop an approach to prioritize identification and validation of a rare ADR to trimethoprim‐sulfamethoxazole causing ...
Feldman K, Miller JO, Doane K, Loftis L, Antoon JW, Downes KJ, Goldman JL.   +6 more
europepmc   +2 more sources

Acute Respiratory Distress Syndrome (ARDS) After Nitric Acid Inhalation

, 2014
Lung injury resulting from inhalation of chemical products continues to be associated with high morbidity and mortality. Concentrated nitric acids are also extremely corrosive fuming chemical liquids.
Gizem Avcı, Bektaş Akpolat, Gülay Kır, Leyla Veral   +3 more
core   +1 more source