Results 61 to 70 of about 117,203 (308)

RNA‐Binding Protein RBM25 Targets the mRNA Stability of GTPase Rab22a to Restrict Viral Entry and Infection

Advanced Science, EarlyView.
This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding, Huiying Chen, Yuyu Jiang, Chunyan Zhao, Jie Bai, Yan Xiang, Zeting Wang, Xixi Wang, Bing Rui, Wanda Tang, Yue Ding, Zhenzhen Zhan, Yunkai Zhang, Xingguang Liu   +13 more
wiley   +1 more source

Circulating leukotriene b4 identifies respiratory complications after trauma [PDF]

, 2012
Background. Leukotriene B4 (LTB4), a proinflammatory lipid mediator correlates well with the acute phase of Acute Respiratory Distress Syndrome (ARDS). Therefore, LTB4-levels were investigated to determine whether they might be a useful clinical marker ...
Henrich, Dirk, Geiger, Emanuel Valentin, Lehnert, Mark, Marzi, Ingo, Emanuel V. Geiger, Ingo Marzi, Dirk Henrich, Birgit Auner, Auner, Birgit, Borna Relja, Relja, Borna, Mark Lehnert   +11 more
core   +1 more source

Rethinking Perioperative Corticosteroids in Esophageal Cancer Surgery: Evidence From an Integrative Meta‐Analysis

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Esophagectomy remains a highly invasive procedure associated with substantial postoperative morbidity. Pulmonary complications, anastomotic leakage, and in‐hospital mortality are of particular concern. Perioperative corticosteroids are often administered to attenuate excessive inflammatory responses; however, the clinical impact in ...
Tomohiko Yasuda, Akihisa Matsuda, Nobutoshi Hagiwara, Yoshiharu Nakamura, Hiroshi Yoshida   +4 more
wiley   +1 more source

Medical Management and Nursing Care of a Patient with Acute Respiratory Distress Syndrome

Bezmiâlem Science, 2022
Acute respiratory distress syndrome (ARDS) is a critical, life-threatening condition involving both lungs, characterized by capillary endothelial damage, diffuse pulmonary infiltration, and oxygen-resistant hypoxemia.
Rukiye Pınar BÖLÜKTAŞ, Ayşenur ÜÇERİZ, Gülşen KALAYCIOĞLU   +2 more
doaj   +1 more source

Pulmonary infections complicating ARDS.

, 2020
Pulmonary infection is one of the main complications occurring in patients suffering from acute respiratory distress syndrome (ARDS). Besides traditional risk factors, dysregulation of lung immune defenses and microbiota may play an important role in ...

core   +1 more source

Potential Survival Benefit of Neoadjuvant Docetaxel, Cisplatin and 5‐Fluorouracil Therapy in Patients With Esophageal Squamous Cell Carcinoma With Multiple Lymph Node Metastases: A Single‐Institute Propensity Score Analysis

Annals of Gastroenterological Surgery, EarlyView.
Although neoadjuvant chemotherapy with fluorouracil, cisplatin, and docetaxel (NAC‐DCF) is the current standard neoadjuvant regimen for esophageal squamous cell carcinoma, its substantial toxicity underscores the need to identify patients who derive the greatest benefit.
Eiji Higaki, Tetsuya Abe, Hironori Fujieda, Shigenori Kadowaki, Tsutomu Tanaka, Masahiro Tajika, Koji Komori, Seiji Ito, Isao Oze, Kei Muro   +9 more
wiley   +1 more source

Histidine Supplementation Stabilizes Hearing and Vision and Improves Growth in HARS1‐Related Autosomal Recessive Disorder Associated With Usher‐Like Symptoms

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Autosomal recessive HARS1‐related disorder (originally described as Usher syndrome type 3B) caused by a homozygous Y454S variant in the histidyl‐tRNA synthetase gene (HARS1) is characterized by progressive sensorineural hearing and vision loss and respiratory deterioration with risk for sudden death following febrile illnesses.
Victoria Mok Siu, Rosan Kenana, Rana Chakrabarti, Sarah D. P. Wilhelm, Joseph Andrews, Susan J. Leat, Christina Parker, Michael Miller, Leslie A. Nangle, Wendy McCaul, Ashfia Chowdhury, Natalie Hutchings, Ryan A. Adams, Lauren Guy, Mandy Rhody, Verena Juncal, Marisa I. Mendes, Desiree E. C. Smith, Gajja S. Salomons, Angelica A. Moresco, Daphne L. McCulloch, D. Holmes Morton, Ilka U. Heinemann, C. Anthony Rupar   +23 more
wiley   +1 more source

ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies.

, 2023
The aim of these guidelines is to update the 2017 clinical practice guideline (CPG) of the European Society of Intensive Care Medicine (ESICM). The scope of this CPG is limited to adult patients and to non-pharmacological respiratory support strategies ...
Piquilloud, L., Gattinoni, L., Herridge, M.S., Bellani, G., Camporota, L., Meyer, N.J., Papazian, L., Ng Gong, M., Pesenti, A., Qiu, H., Riviello, E., Villar, J., Matthay, M.A., Moss, M., Myatra, S.N., Karagiannidis, C., Perner, A., Ware, L.B., Antonelli, M., Laffey, J.G., Baroncelli, F., Juffermans, N.P., Brodie, D., Kwizera, A., Arabi, Y.M., Guérin, C., Hough, C.L., Combes, A., Zampieri, F.G., Mercat, A., Grasselli, G., Stapleton, R.D., Summers, C., Amato, MBP, Ranieri, M.V., Azoulay, E., D'Arrigo, S., Blackwood, B., Brochard, L., Poole, D., Hodgson, C., Weiss, B., Beitler, J.R., Slutsky, A.S., Einav, S., Calfee, C.S., Mancebo, J., Thompson, T.B., Ferguson, N.D., McAuley, D.F., Bos, LDJ, Valente Barbas, C.S., De Backer, D., Demoule, A., Kesecioglu, J., Pellegrini, M., Fan, E., Burns, KEA, Patel, B.K., Bellingan, G., Jaber, S., Frat, J.P., Cecconi, M., Munshi, L.   +63 more
core   +1 more source

Early evolution of the gular musculature and its innervation in ray‐finned fishes

The Anatomical Record, EarlyView.
Abstract Gular muscles are an important but often overlooked component of cranial anatomy in bony fishes. They are located on the ventral surface of the head and are derived from the mandibular and hyoid arches. We present a comprehensive review of the gular musculature and its innervation across early diverging actinopterygian lineages. By integrating
Aléssio Datovo, Paulo Presti, George Vita, Murilo N. L. Pastana, Luiz A. W. Peixoto   +4 more
wiley   +1 more source

COVID-ARDS: A Vascular Endotype

, 2020
COVID-19, the pandemic caused by the SARS-CoV-2 coronavirus can progress to pneumonia and Acute Respiratory Distress Syndrome (ARDS), resulting in an extraordinary level of ICU utilization and considerable mortality.
Andrew Vaughan, Douglas Cines, Nuala Meyer, Nilam Mangalmurti, John Reilly   +4 more
core   +1 more source