Results 61 to 70 of about 288,918 (291)

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

Advanced Science, EarlyView.
In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin, Xinran Deng, Haonan Wang, Yamei Jiang, Jian Sun, Hailin Ding, Ming Ye, Xiaoting Wang, Yu Wang, Li Yuan, Zhenju Song, Xinhua Lin, Shenfei Sun, Ning Jiang   +13 more
wiley   +1 more source

Simvastatin to reduce pulmonary dysfunction in patients with acute respiratory distress syndrome: the HARP-2 RCT

Efficacy and Mechanism Evaluation, 2018
Background: Acute lung injury is a common devastating clinical syndrome characterised by life-threatening respiratory failure requiring mechanical ventilation and multiple organ failure, and is a major cause of morbidity and mortality.
Daniel F McAuley, John G Laffey, Cecilia M O’Kane, Gavin D Perkins, Brian Mullan, Thomas J Trinder, Paul Johnston, Phillip A Hopkins, Andrew J Johnston, Lynn Murphy, Christine McNally, Ashley M Agus, Clíona McDowell, Colette Jackson   +13 more
doaj   +1 more source

Comparing lung mechanics of patients with COVID related respiratory distress syndrome versus non-COVID acute respiratory distress syndrome: a retrospective observational study

Journal of Mechanical Ventilation, 2022
Background Most patients admitted to the intensive care unit with coronavirus disease (COVID-19) develop severe respiratory failure. Understanding lung mechanics helps to guide protective mechanical ventilation, improve oxygenation, and reduce the ...
Francisco Chacón-Lozsán, Péter Tamási   +1 more
doaj   +1 more source

Effect of Rosuvastatin on Acute Kidney Injury in Sepsis-Associated Acute Respiratory Distress Syndrome. [PDF]

, 2018
Background:Acute kidney injury (AKI) commonly occurs in patients with sepsis and acute respiratory distress syndrome (ARDS). Objective:To investigate whether statin treatment is protective against AKI in sepsis-associated ARDS.
Hsu, Raymond K, Levitt, Joseph E, Liu, Kathleen D, Matthay, Michael A, Thompson, Boyd Taylor, Truwit, Jonathon D   +5 more
core   +3 more sources

Beyond Extracellular Vesicle (EV) Hype: Practical Solutions and Remaining Hurdles in EV Research, Manufacturing, and Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale mediators of intercellular communication with diverse molecular cargoes that reflect their cell of origin. Advances in isolation, detection, and single‐particle analytics have revealed increasing molecular and functional heterogeneity, while exposing limitations in how EV identity and activity are ...
David J. Lundy, Zoe L. Chau, Sheng‐You Chen, Nanami Fujisawa, John J. Hill, Barnett M. Hsu, Joanne K. Liu, Karol W. Mai, James J. Lai   +8 more
wiley   +1 more source

Plasma CC16 levels are associated with development of ALI/ARDS in patients with ventilator-associated pneumonia: a retrospective observational study [PDF]

, 2009
Background Despite consensus criteria, diagnosing acute lung injury, or its more severe form acute respiratory distress syndrome (ALI/ARDS) remains challenging.
Rogier M Determann, Julian L Millo, Sam Waddy, Rene Lutter, Chris S Garrard, Marcus J Schultz, M Klompas, C Brun-Buisson, TD Girard, AP Wheeler, GR Bernard, ND Ferguson, E Estenssoro, F Broeckaert, T Uchida, KE Greene, A Ishizaka, M Shirasawa, D Hartl, N Kohno, MD Eisner, O Lesur, RM Determann, CH A'Court, JL Millo, JC Marshall, B Afessa, J Pugin, JF Murray, RM Determann, M Robin, N Shijubo, HP Wiedemann, MJ Schultz, ND Ferguson, A Blomberg, G Bonetto, O Michel, AM Bernard, M Fartoukh, O Lesur, H Wittkowski, SF Yan   +42 more
core   +3 more sources

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

Tetrahedral DNA Nanostructure‐Based Biomimetic Nanovesicles Attenuate Sepsis‐Associated ARDS by Suppressing Glycolysis via the BMAL1/PFKFB3 Axis

Advanced Science, EarlyView.
Upon inhalation, RM@TNT could persist long‐term in the diseased lungs, while undergoing disintegration to release TNT specifically within the ROS‐rich pathological microenvironments of SA‐ARDS. The released TNT was then precisely delivered to AMs via Tuftsin, where it released Nob intracellularly to activate BMAL1 expression, thus inhibiting AM ...
Yunlong Zhang, Bin Li, Zhijin Fan, Yan Yan, Fei Ma, Changting He, Shiping Liu, Mingliang Pan, Zhou Pan, Huijuan Wang, Xinting Fu, Jiamei Wang, Yue Jia, Qin Gu, Duo Jiang, Xueting Liu, Bohua Ren, Qinqin Wang, Yuehua Hei, Han Duan, Yanqiu Wu, Zihui Wei, Liying Zhan, Yuhui Liao   +23 more
wiley   +1 more source

Novel anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury. [PDF]

, 2018
BACKGROUND: Tumour necrosis factor alpha (TNF-α) is a pleiotropic cytokine with both injurious and protective functions, which are thought to diverge at the level of its two cell surface receptors, TNFR1 and TNFR2.

core   +2 more sources

ML Workflows for Screening Degradation‐Relevant Properties of Forever Chemicals

Advanced Science, EarlyView.
The environmental persistence of per‐ and polyfluoroalkyl substances (PFAS) necessitates efficient remediation strategies. This study presents physics‐informed machine learning workflows that accurately predict critical degradation properties, including bond dissociation energies and polarizability.
Pranoy Ray, Andrew R. Castillo, Manoj Kolel‐Veetil, Surya R. Kalidindi   +3 more
wiley   +1 more source