Results 61 to 70 of about 30,897 (254)

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies.

, 2023
The aim of these guidelines is to update the 2017 clinical practice guideline (CPG) of the European Society of Intensive Care Medicine (ESICM). The scope of this CPG is limited to adult patients and to non-pharmacological respiratory support strategies ...
Piquilloud, L., Gattinoni, L., Herridge, M.S., Bellani, G., Camporota, L., Meyer, N.J., Papazian, L., Ng Gong, M., Pesenti, A., Qiu, H., Riviello, E., Villar, J., Matthay, M.A., Moss, M., Myatra, S.N., Karagiannidis, C., Perner, A., Ware, L.B., Antonelli, M., Laffey, J.G., Baroncelli, F., Juffermans, N.P., Brodie, D., Kwizera, A., Arabi, Y.M., Guérin, C., Hough, C.L., Combes, A., Zampieri, F.G., Mercat, A., Grasselli, G., Stapleton, R.D., Summers, C., Amato, MBP, Ranieri, M.V., Azoulay, E., D'Arrigo, S., Blackwood, B., Brochard, L., Poole, D., Hodgson, C., Weiss, B., Beitler, J.R., Slutsky, A.S., Einav, S., Calfee, C.S., Mancebo, J., Thompson, T.B., Ferguson, N.D., McAuley, D.F., Bos, LDJ, Valente Barbas, C.S., De Backer, D., Demoule, A., Kesecioglu, J., Pellegrini, M., Fan, E., Burns, KEA, Patel, B.K., Bellingan, G., Jaber, S., Frat, J.P., Cecconi, M., Munshi, L.   +63 more
core   +1 more source

MetaboSense: An Integrated Quantum Dot‐Mediated Aptamer Assay and Modular Microfluidic Platform for Continuous In‐Line Monitoring of Lung Metabolism During Ex Vivo Perfusion

Advanced Science, EarlyView.
MetaboSense is a first‐of‐its‐kind microfluidic platform enabling continuous, in‐line monitoring of glucose and lactate during ex vivo lung perfusion. Combining a quantum dot–mediated aptamer assay with mixing, depletion, and optofluidic detection modules, it achieves 60–s temporal resolution and shows strong agreement with standard blood gas analyzers,
Sanjana Srikant, Pouyan Keshavarz Motamed, Thomas Borrillo, Lielle Ronen, Gabriel Siebiger, Guillermo Garza, Hesam Abouali, Md Fahim Al Fattah, Ines Jaber, Dayan Ban, Marcelo Cypel, Mingyao Liu, Shaf Keshavjee, Andrew T. Sage, Mahla Poudineh   +14 more
wiley   +1 more source

Prone position : yes or no?

, 2011
Prone positioning has been used for over 30 years in the management of patients with acute respiratory distress syndrome (ARDS). This maneuver has consistently proven capable of improving oxygenation in patients with acute respiratory failure.
L. Gattinoni
core   +2 more sources

Beta Agonist Lung Injury TrIal-2 (BALTI-2) trial protocol : a randomised, double-blind, placebo-controlled of intravenous infusion of salbutamol in the acute respiratory distress syndrome [PDF]

, 2011
Background: The Acute Respiratory Distress Syndrome (ARDS) is a common cause of respiratory failure in critically ill patients. Experimental studies suggest that treatment with beta agonists may be helpful in ARDS.
McCabe Chris, Young Duncan, Lamb, Sarah E, Young, Duncan S., McCabe, Chris, Gao, F, Perkins, Gavin D., Gates, S, Smith, F. Gao, Lamb, S. E., Chris McCabe, Fang Gao, Young, D, Duncan Young, Gao, Fang; id_orcid, Gao Fang, Perkins, GD, Young, Duncan, Gates, Simon, Lamb, Sarah, Sarah E Lamb, Gavin D Perkins, Perkins, Gavin D, Simon Gates, Lamb Sarah E, Gates Simon, McCabe, C, Perkins Gavin D, Lamb, SE   +28 more
core   +2 more sources

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Medical Management and Nursing Care of a Patient with Acute Respiratory Distress Syndrome

Bezmiâlem Science, 2022
Acute respiratory distress syndrome (ARDS) is a critical, life-threatening condition involving both lungs, characterized by capillary endothelial damage, diffuse pulmonary infiltration, and oxygen-resistant hypoxemia.
Rukiye Pınar BÖLÜKTAŞ, Ayşenur ÜÇERİZ, Gülşen KALAYCIOĞLU   +2 more
doaj   +1 more source

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

Advanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim, Minju Lee, Yiming Wang, Eunjin Choi, Ji Sun Park, Kyungmin Park, Hayoung Jeon, Donghyun Kim, Donghyun Lee, Yeeun Lee, Kee‐Pyo Kim, Eunha Kim, Heebeom Koo   +12 more
wiley   +1 more source

Mitochondria‐Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA‐Driven Inflammation at the Source

Advanced Science, EarlyView.
Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li, Juan Cao, Yu‐Lin Wang, Yu‐Han Fan, Jia‐Qi Xu, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +7 more
wiley   +1 more source