Results 71 to 80 of about 117,311 (310)

Circulating leukotriene b4 identifies respiratory complications after trauma [PDF]

, 2012
Background. Leukotriene B4 (LTB4), a proinflammatory lipid mediator correlates well with the acute phase of Acute Respiratory Distress Syndrome (ARDS). Therefore, LTB4-levels were investigated to determine whether they might be a useful clinical marker ...
Henrich, Dirk, Geiger, Emanuel Valentin, Lehnert, Mark, Marzi, Ingo, Emanuel V. Geiger, Ingo Marzi, Dirk Henrich, Birgit Auner, Auner, Birgit, Borna Relja, Relja, Borna, Mark Lehnert   +11 more
core   +1 more source

The impact of the new acute respiratory distress syndrome (ARDS) criteria on Berlin criteria ARDS patients: a multicenter cohort study [PDF]

, 2023
Objective The European Society of Intensive Care Medicine (ESICM) recently recommended changes to the criteria of acute respiratory distress syndrome (ARDS), patients with high-flow oxygen were included, however, the effect of these changes remains ...
Hening Wu, Zhao, Lina, Lina Zhao, Shen, Yuehao, Li, Yun, Li, Xuguang, Liu, Haiying, Yun Li, Xie, Keliang, Yuehao Shen, Nannan Zhang, Su, FUHONG, Wu, Hening, Haiying Liu, Xuguang Li, Keliang Xie, Zhang, Nannan, Fuhong Su   +17 more
core   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Overview of intra-ARDS multi-omic signatures within each ARDS. [PDF]

, 2022
a. Molecules associated with each of the two clinical manifestations that could be compared across ARDS groups (AKI and platelet count) for each omics layer. 249 molecules were associated with AKI and 111 with platelet count in the ARDS groups.
William Whalen (11995007), John Harrington (6164594), Mustafa Buyukozkan (10880257), Sergio Alvarez-Mulett (11995010), Karsten Suhre (67967), Will Simmons (10292618), Edward Schenck (13822787), Elisa Benedetti (4886821), Richa Batra (111078), Augustine M. K. Choi (8362764), Mary E. Choi (4557232), Jan Krumsiek (127460), Soo Jung Cho (11995004), Kelsey Chetnik (13822784), Frank Schmidt (207186), Luis G. Gomez-Escobar (13822781), Katherine L. Hoffman (10704437)   +16 more
core   +1 more source

Medical Management and Nursing Care of a Patient with Acute Respiratory Distress Syndrome

Bezmiâlem Science, 2022
Acute respiratory distress syndrome (ARDS) is a critical, life-threatening condition involving both lungs, characterized by capillary endothelial damage, diffuse pulmonary infiltration, and oxygen-resistant hypoxemia.
Rukiye Pınar BÖLÜKTAŞ, Ayşenur ÜÇERİZ, Gülşen KALAYCIOĞLU   +2 more
doaj   +1 more source

Potential Survival Benefit of Neoadjuvant Docetaxel, Cisplatin and 5‐Fluorouracil Therapy in Patients With Esophageal Squamous Cell Carcinoma With Multiple Lymph Node Metastases: A Single‐Institute Propensity Score Analysis

Annals of Gastroenterological Surgery, EarlyView.
Although neoadjuvant chemotherapy with fluorouracil, cisplatin, and docetaxel (NAC‐DCF) is the current standard neoadjuvant regimen for esophageal squamous cell carcinoma, its substantial toxicity underscores the need to identify patients who derive the greatest benefit.
Eiji Higaki, Tetsuya Abe, Hironori Fujieda, Shigenori Kadowaki, Tsutomu Tanaka, Masahiro Tajika, Koji Komori, Seiji Ito, Isao Oze, Kei Muro   +9 more
wiley   +1 more source

Integrating Reinforcement Learning With Explainable Artificial Intelligence for Real‐Time Clinical Decision Support in Dynamic Healthcare Environments

Advanced Intelligent Systems, EarlyView.
A hybrid Reinforcement Learning–Explainable AI framework integrates SHAP and LIME explanations directly into a Deep Q‐Network inference loop for real‐time ICU decision support. Trained on 18 142 mechanically ventilated stays from the eICU database, the system attains 93.0% decision accuracy, 20% fewer errors than RL alone, and a 91% clinician trust ...
Jannatul Ferdaus Disha, MD Faiaz Zaman Dehan, Kazi Md. Tanvir Anzum   +2 more
wiley   +1 more source

Integrating developmental and macroevolutionary approaches reveals a staminodial origin of all alternisepalous organs in Caryophyllaceae

American Journal of Botany, EarlyView.
Abstract Premise The identity of sterile floral organs in second‐whorl, alternisepalous positions within Caryophyllaceae remains contentious, having been described as staminodes, “petaloids,” or petals homologous with those of other Pentapetalae. Limited ingroup and outgroup sampling and floral developmental data and inadequate phylogenetic comparative
Riley J. Rees, Andrea D. Appleton, John J. Schenk   +2 more
wiley   +1 more source

Histidine Supplementation Stabilizes Hearing and Vision and Improves Growth in HARS1‐Related Autosomal Recessive Disorder Associated With Usher‐Like Symptoms

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Autosomal recessive HARS1‐related disorder (originally described as Usher syndrome type 3B) caused by a homozygous Y454S variant in the histidyl‐tRNA synthetase gene (HARS1) is characterized by progressive sensorineural hearing and vision loss and respiratory deterioration with risk for sudden death following febrile illnesses.
Victoria Mok Siu, Rosan Kenana, Rana Chakrabarti, Sarah D. P. Wilhelm, Joseph Andrews, Susan J. Leat, Christina Parker, Michael Miller, Leslie A. Nangle, Wendy McCaul, Ashfia Chowdhury, Natalie Hutchings, Ryan A. Adams, Lauren Guy, Mandy Rhody, Verena Juncal, Marisa I. Mendes, Desiree E. C. Smith, Gajja S. Salomons, Angelica A. Moresco, Daphne L. McCulloch, D. Holmes Morton, Ilka U. Heinemann, C. Anthony Rupar   +23 more
wiley   +1 more source