Results 51 to 60 of about 58,033 (264)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Practical approach for modifying existing geocoding system from equal angular to equal area [PDF]

Икономика и компютърни науки, 2023
Geocoding systems are essential for the rapid processing of large volumes of spatial data. There are numerous geocoding systems, each of which divides the space into subspaces with a unique geometric shape and employs a different approach of creating its
Pavel Petrov
doaj  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

CartoSR: An attention-enhanced deep GANs for single map super resolution reconstruction

International Journal of Applied Earth Observations and Geoinformation
Maps are fundamental media for people to comprehend the spatial and temporal dimensions of a place. Currently, the majority of maps are generated through volunteered efforts, which significantly extends the critical and participatory aspects of ...
Xiran Zhou, Honghao Li, Zhenfeng Shao, Wenwen Li, Zhigang Yan   +4 more
doaj   +1 more source

Controlling chaos in area-preserving maps [PDF]

Physica D: Nonlinear Phenomena, 2005
We describe a method of control of chaos that occurs in area-preserving maps. This method is based on small modifications of the original map by addition of a small control term. We apply this control technique to the standard map and to the tokamap.
Chandre, Cristel, Vittot, Michel, Elskens, Yves, Ciraolo, Guido, Pettini, Marco   +4 more
openaire   +4 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Two-Layer Fragile Watermarking Method Secured with Chaotic Map for Authentication of Digital Holy Quran

The Scientific World Journal, 2014
This paper presents a novel watermarking method to facilitate the authentication and detection of the image forgery on the Quran images. Two layers of embedding scheme on wavelet and spatial domain are introduced to enhance the sensitivity of fragile ...
Mohammed S. Khalil, Fajri Kurniawan, Muhammad Khurram Khan, Yasser M. Alginahi   +3 more
doaj   +1 more source

Area-Preserving Mappings for the Visualization of Medical Structures [PDF]

, 2003
In this note, we present a method for flattening anatomical surfaces such as branched vessels and intestinal tracts in an area-preserving way. This method is based on the theory of optimal mass transport and conformal mapping of surfaces. The flattened representations differ minimally from conformality in a certain precise sense. Potential applications
Lei Zhu 0001, Steven Haker, Allen R. Tannenbaum   +2 more
openaire   +1 more source