Results 101 to 110 of about 156,547 (252)

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Boosting Frequency Stability in Multi-Microgrid Systems With an Innovative Dual-Hybrid Fractional Control Scheme Integrating Demand Response

IEEE Access
Modern electrical power grids are characterized by a significant increase in renewable energy generation, often complemented by energy storage systems. Integrating these storage devices helps to offset the challenges posed by the decreased system inertia
Mokhtar Aly, Emad A. Mohamed, Emad M. Ahmed   +2 more
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Contributions of renin-angiotensin system-related gene interactions to obesity in a Chinese population.

PLoS ONE, 2012
BackgroundGene-gene interactions may be partly responsible for complex traits such as obesity. Increasing evidence suggests that the renin-angiotensin system (RAS) contributes to the etiology of obesity.
Jian-Bo Zhou, Chang Liu, Wen-Yan Niu, Zhong Xin, Mei Yu, Jian-Ping Feng, Jin-Kui Yang   +6 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Optimal Bidding Strategy for PV and BESSs in Joint Energy and Frequency Regulation Markets Considering Carbon Reduction Benefits

Journal of Modern Power Systems and Clean Energy
Photovoltaic (PV) and battery energy storage systems (BESSs) are key components in the energy market and crucial contributors to carbon emission reduction targets.
Jing Bian, Yuheng Song, Chen Ding, Jianing Cheng, Shiqiang Li, Guoqing Li   +5 more
doaj   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Fast Load Control with Stochastic Frequency Measurement [PDF]

, 2011
Matching demand with supply and regulating frequency are key issues in power system operations. Flexibility and local frequency measurement capability of loads offer new regulation mechanisms through load control.
Low, Steven H., Topcu, Ufuk, Zhao, Changhong   +2 more
core   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Space-Based Cosmic-Ray and Gamma-Ray Detectors: a Review [PDF]

, 2014
Prepared for the 2014 ISAPP summer school, this review is focused on space-borne and balloon-borne cosmic-ray and gamma-ray detectors. It is meant to introduce the fundamental concepts necessary to understand the instrument performance metrics, how they ...
Baldini, Luca
core