Results 91 to 100 of about 18,375 (248)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

LQI-Type Load-Frequency Control with the First-Order Holder Improved for Ramp Load Disturbances [PDF]

This paper presents a new method of designing discrete-type load frequency regulator with the first-order sampling holder which improves control performance against rampwise load disturbances.
Miyagi, Hayao, 宮城, 隼夫, 山下, 勝己, Yamashita, Katsumi   +3 more
core  

AUTOMATIC GENERATION CONTROL IN MULTI AREA INTERCONNECTED POWER SYSTEM USING PID CONTROLLER BASED ON GA AND PSO

Diyala Journal of Engineering Sciences, 2015
The goal of paper is to maintain the frequency and tie line power changes are maintained at their scheduled values, so in this paper presents two methods for determination of the optimal (Proportional-Integral-Derivate) PID parameters for Automatic ...
Ghassan Abdullah Salman
doaj  

Adaptive Automatic Generation Control in Multi-Area Power Systems: A Deep Reinforcement Learning Approach for Model-Based Controller Tuning

IEEE Access
The increasing penetration of renewable energy sources (RES) reduces power system inertia, causing severe frequency excursions following disturbances.
Mkhutazi Mditshwa, Komla A. Folly, David T. O. Oyedokun   +2 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Contributions of renin-angiotensin system-related gene interactions to obesity in a Chinese population.

PLoS ONE, 2012
BackgroundGene-gene interactions may be partly responsible for complex traits such as obesity. Increasing evidence suggests that the renin-angiotensin system (RAS) contributes to the etiology of obesity.
Jian-Bo Zhou, Chang Liu, Wen-Yan Niu, Zhong Xin, Mei Yu, Jian-Ping Feng, Jin-Kui Yang   +6 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Probabilistic Prediction of the Area Control Error Using Normalizing Flows

Balancing generation and load is a central challenge in power systems, particularly those with a high share of renewable generation. The area control error (ACE) quantifies the current power mismatch in a certain area of the power grid and thus provides ...
Hartmann, Carsten, Dahmen, Manuel, Cramer, Eike, Mayer, Pablo, Witthaut, Dirk   +4 more
core  

Optimal Bidding Strategy for PV and BESSs in Joint Energy and Frequency Regulation Markets Considering Carbon Reduction Benefits

Journal of Modern Power Systems and Clean Energy
Photovoltaic (PV) and battery energy storage systems (BESSs) are key components in the energy market and crucial contributors to carbon emission reduction targets.
Jing Bian, Yuheng Song, Chen Ding, Jianing Cheng, Shiqiang Li, Guoqing Li   +5 more
doaj   +1 more source