Results 91 to 100 of about 156,547 (252)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Four-Area Load Frequency Control of an Interconnected Power System Using Neuro-Fuzzy Hybrid Intelligent Proportional and Integral Control Approach

Journal of Intelligent Systems, 2013
This article presents a novel control approach, hybrid neuro-fuzzy (HNF), for the load frequency control (LFC) of a four-area interconnected power system.
Giri Surya Prakash, Sinha Sunil Kumar
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Observations of the December 13 and 14, 2006, Solar Particle Events in the 80 MeV/n - 3 GeV/n range from space with PAMELA detector

, 2011
We present the space spectrometer PAMELA observations of proton and helium fluxes during the December 13 and 14, 2006 solar particle events. This is the first direct measurement of the solar energetic particles in space with a single instrument in the ...
A. Bruno, A. G. Mayorov, A. Leonov, A. M. Galper, A. Monaco, A. N. Kvashnin, A. V. Karelin, A. Vacchi, Abbasi, ACE, Battistoni, Bieber, Bombardieri, C. De Santis, C. Pizzolotto, Casolino, D. Campana, De Simone, E. A. Bogomolov, E. Mocchiutti, E. Vannuccini, F. Cafagna, F. Palma, Ferrari, G. A. Bazilevskaya, G. C. Barbarino, G. Castellini, G. Jerse, G. Osteria, G. Vasilyev, G. Zampa, J. Wu, Krymskii, L. Bonechi, L. Consiglio, L. Grishantseva, L. Marcelli, L. Rossetto, Laboratory, Lee, M. Boezio, M. Bongi, M. Casolino, M. P. De Pascale, M. Pearce, M. Ricci, M. Simon, McCracken, Moraal, N. De Simone, N. Mori, N. Nikonov, N. Zampa, NOAA-STP., NOAA., NOAA., O. Adriani, P. Carlson, P. Papini, P. Picozza, P. Spillantini, R. Bellotti, R. Carbone, R. Sarkar, R. Sparvoli, S. A. Voronov, S. B. Ricciarini, S. Borisov, S. Bottai, S. V. Koldashov, S. Y. Krutkov, Shea, Timashkov, V. Bonvicini, V. Di Felice, V. Formato, V. G. Zverev, V. Malakhov, V. V. Mikhailov, Vashenyuk, W. Gillard, W. Menn, Y. I. Stozhkov, Y. T. Yurkin   +83 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

AUTOMATIC GENERATION CONTROL IN MULTI AREA INTERCONNECTED POWER SYSTEM USING PID CONTROLLER BASED ON GA AND PSO

Diyala Journal of Engineering Sciences, 2015
The goal of paper is to maintain the frequency and tie line power changes are maintained at their scheduled values, so in this paper presents two methods for determination of the optimal (Proportional-Integral-Derivate) PID parameters for Automatic ...
Ghassan Abdullah Salman
doaj  

Adaptive Automatic Generation Control in Multi-Area Power Systems: A Deep Reinforcement Learning Approach for Model-Based Controller Tuning

IEEE Access
The increasing penetration of renewable energy sources (RES) reduces power system inertia, causing severe frequency excursions following disturbances.
Mkhutazi Mditshwa, Komla A. Folly, David T. O. Oyedokun   +2 more
doaj   +1 more source

IAC user manual [PDF]

The User Manual for the Integrated Analysis Capability (IAC) Level 1 system is presented. The IAC system currently supports the thermal, structures, controls and system dynamics technologies, and its development is influenced by the requirements for ...
Beste, D. L., Gregg, J., Vos, R. G.
core   +1 more source