Results 71 to 80 of about 18,375 (248)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Feasibility of decomposing one-minute average area control error for apportioning load -frequency regulation costs

, 2000
Rapid and widely varying loads can adversely affect control performance of a control area. To ensure the reliability of the interconnection, sanctions or penalties can be imposed on a control area when it fails to comply with NERC control performance ...
Hoonchareon, Naeb-boon
core  

Regulation Signal Design and Fast Frequency Control With Energy Storage Systems

, 2021
This paper presents a novel H2 filter design procedure to optimally split the Frequency Regulation (FR) signal between conventional and fast regulating Energy Storage System (ESS) assets, considering typical Communication Delays (CDs). The filter is then
Simpson-Porco, John W., Bhattacharya, Kankar, Cañizares, Claudio A., Guzman E., Noela Sofia, Arriaga, Mariano, Sohm, Daniel   +5 more
core   +1 more source

Design and assessment of fuzzy controllers for LFC of multisource electrical system: A novel Sinh-Cosh (ShCh) technique

Results in Engineering
This research manuscript comprehensively evaluates various fuzzy controllers and optimization methodologies aimed at enhancing load-frequency control (LFC) within an electrical grid system subjected to diverse electrical disturbances.
Sarat Chandra Swain, Biranchi Kumar Mahala, Prakash Chandra Sahu, Sunil Kumar Bhatta, Ghanshyam G. Tejani, Seyed Jalaleddin Mousavirad   +5 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Algorythm for Close-to-Real-Time Monitoring of Calculation Quality of Area- and Block Control Error

, 2019
V letu 2017 je bila sprejeta nova evropska zakonodaja, ki od sistemskih operaterjev prenosnih omrežij zahteva realizacijo orodja za spremljanje kakovosti izračuna napake regulacijskega območja (ACE). Pričujoče delo opredeljuje razvoj, zasnovo in izdelavo
PODBREGAR, BOŠTJAN
core  

Data Forgery Detection in Automatic Generation Control: Exploration of Automated Parameter Generation and Low-Rate Attacks

, 2021
Automatic Generation Control (AGC) is a key control system utilized in electric power systems. AGC uses frequency and tie-line power flow measurements to determine the Area Control Error (ACE).
Dubasi, Yatish R
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source