Results 61 to 70 of about 18,375 (248)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

A Distributed AGC Method considering Two-Channel Random Delays and Their Difference between Interconnected Power Systems

Journal of Electrical and Computer Engineering, 2019
With the emergence of the concept of smart grid, the networked automatic generation control (AGC) method has been more and more important for secondary frequency control due to its characteristics such as openness and flexibility.
Xilin Zhao, Zhenyu Lin, Bo Fu, Yang Yang, Jimin Ma   +4 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Improvement of CPS in High-Proportion New-Energy Power System and Practical Application

Energies
With the integration of high-penetration new energy, the increasing disparities in power source structures across interconnected power system control areas have become prominent.
Zhen Huang, Wenbo Yang, Lei Chen, Kaiyuan Hou, Deming Xia, Fei Xu, Yong Min, Ziye Zhou   +7 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

SUPPLEMENTARY DC CONTROL IN A TWO AREA AC/DC POWER SYSTEM [PDF]

, 1992
In this thesis results of research are reported for a study of the dynamic performance of a two-area power system interconnected by AC and DC tie-lines.
Castellanos Iturrate, Jose Miguel
core  

IMECE2002-DCS-33445 DEVELOPMENT OF AN INTELLIGENT AUTOMATIC GENERATION CONTROL SYSTEM FOR ELECTRICAL POWER PLANTS [PDF]

, 2020
The United States electric grid is a complex structure that requires high precision control of frequency and tieline power flows among different generation areas.
Rahmat A Shoureshi, Benjamin Hoffner, R A Kramer   +2 more
core  

An Assessment of the Impact of Uncertainty on Automatic Generation Control Systems [PDF]

, 2016
This paper proposes a framework to quantify the impact of uncertainty that arises from load variations, renewable-based generation, and noise in communication channels on the automatic generation control (AGC) system.
Sauer, P. W., Apostolopoulou, D., Dominguez-Garcia, A. D.   +2 more
core   +1 more source

Load Frequency Control in Multi-Area Power Systems Using Incremental Proportional–Integral–Derivative and Model-Free Adaptive Control

Applied System Innovation
Maintaining frequency stability in modern multi-area interconnected power systems has become increasingly challenging due to the stochastic nature of wind power and reduced effective system inertia.
Md Asif Shaharear, Chengyu Zhou, Shahin Shaikh, Md Mehedy Hasan Faruk   +3 more
doaj   +1 more source