Results 81 to 90 of about 156,547 (252)

Health of American Indian and Alaska Native Elders in California [PDF]

, 2010
Analyzes the health risks, health status, and utilization of and access to health services among American Indians/Alaska Natives age 55 and older in California, as well as trends in demographics and underlying factors including economic ...
Andrea N. Garcia, Delight E. Satter, Lauren M. Smith, Steven P. Wallace   +3 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Design and assessment of fuzzy controllers for LFC of multisource electrical system: A novel Sinh-Cosh (ShCh) technique

Results in Engineering
This research manuscript comprehensively evaluates various fuzzy controllers and optimization methodologies aimed at enhancing load-frequency control (LFC) within an electrical grid system subjected to diverse electrical disturbances.
Sarat Chandra Swain, Biranchi Kumar Mahala, Prakash Chandra Sahu, Sunil Kumar Bhatta, Ghanshyam G. Tejani, Seyed Jalaleddin Mousavirad   +5 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

A Two-Layer Control Strategy for the Participation of Energy Storage Battery Systems in Grid Frequency Regulation

Energies
A two-layer control strategy for the participation of multiple battery energy storage systems in the secondary frequency regulation of the grid is proposed to address the frequency fluctuation problem caused by the power dynamic imbalance between the ...
Pan Zhang, Shijin Xin, Yunwen Wang, Qing Xu, Chunsheng Chen, Wei Chen, Haiying Dong   +6 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

New Mixture Additives for Sustainable Bituminous Pavements [PDF]

, 2018
In an effort to improve mechanical properties of asphalt concrete, an exploratory research using mixture additives was attempted. Two different types of additives on two material scales were used: asphalt concrete (AC) level and binder level.
Kim, Yong-Rak, Mukristu Nsengiyumva, Gabriel, Santosh, Kommidi, Xu, Helan, Yang, Yiqi   +4 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Sliding Mode Without Reaching Phase Design for Automatic Load Frequency Control of Multi-Time Delays Power System

IEEE Access
The automatic load frequency control (ALFC) is designed based on integral sliding mode control (ISMC) without reaching time for a multi-time delay power system (MTDPS) with the system disturbances and uncertainties.
Dao Huy Tuan, Jan Pidanic, Van van Huynh, Vo Hoang Duy, Nguyen Huu Khanh Nhan   +4 more
doaj   +1 more source