Results 61 to 70 of about 6,402,628 (197)

The ongoing oleoylethanolamide story: Therapeutic implications in the control of obesity and its comorbidities

British Journal of Pharmacology, EarlyView.
The global burden of obesity continues to rise, demanding effective pharmacological strategies for individuals in whom prevention alone is insufficient. Recent incretin‐based and multi‐agonist therapies have delivered unprecedented weight loss, demonstrating that the simultaneous modulation of multiple metabolic pathways can optimize body weight ...
Marzia Friuli, Alessia Campagna, Barbara Eramo, Christian Sepe, Annarita Zuena, Silvana Gaetani, Adele Romano   +6 more
wiley   +1 more source

AMPA receptor activation of area postrema neurons

, 1999
This study reports on the effects of activation of ionotropic glutamate receptors on area postrema neuron cytosolic calcium concentration ([Ca2+]i). In 140 of 242 area postrema neurons isolated from postnatal rats, application of 100 μMl-glutamate (l-Glu)
Kathy A. Lindsley, Meredith Hay
core   +1 more source

Clinicopathological Features of Pakistani Patients with Anti Aquaporin-4 (Aqp-4) Antibody Positive Neuromyelitis Optica Spectrum Disorder (NMOSD): A Comparison with Local, Regional and International StudiesOPTICA SPECTRUM DISORDER(NMOSD)-A COMPARISON WITH LOCAL, REGIONAL AND INTERNATIONAL STUDIES

Pakistan Armed Forces Medical Journal
  Objective: To characterize clinicopathological characteristics of patients with anti AQP-4 antibody positive Neuromyelitis Optica Spectrum Disorder in local population in order to facilitate clinicians in timely diagnosis and treatment of this rare ...
Muhammad Zain Arshad, Muhammad Omair Riaz, Dawood Ahmad, Muhammad Hussain, Ayesha Tanveer, Muhammad Aftab Hassan   +5 more
doaj   +1 more source

Investigation of the mechanisms and modulation of irinotecan‐induced emesis in Suncus murinus

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Irinotecan is a widely used chemotherapeutic agent that frequently causes nausea and emesis. Its emetic mechanism of action is poorly understood and the choice of drugs to reduce nausea and emesis is largely empirical. Experimental Approach Using Suncus murinus, we examined (i) the dose–response and temporal profile of ...
Zengbing Lu, Julia Y. H. Liu, Yasuhiro Nakagami, Zitong Li, Xiaofei Huang, Man P. Ngan, Dexuan Cui, John A. Rudd   +7 more
wiley   +1 more source

Neuromyelitis Optica Spectrum of Diseases Involving the Area Postrema in a Nigerian: A Case Report

, 2022
The clinical features and findings on neuroimaging of Neuromyelitis optica Spectrum of diseases NMOSD are distinct1,2 but affectation of the Area Postrema is rare.3-5 This is a case presentation on Neuro-myelitis Optica involving the Area Postrema in a ...
Uchenna Nwako
core  

Síndrome del área Postrema como manifestación inicial de neuromielítis óptica: Reporte de caso

Revista Científica CMDLT
Introducción. El síndrome del área postrema (SAP) constituye una manifestación neurológica distintiva pero subestimada, del trastorno del espectro de la neuromielítis óptica (NMOSD), una enfermedad inflamatoria autoinmune grave que afecta principalmente
Betania Nazareth Silva Gonzalez, Leyda Josefina Aldana Delgado, Elizabeth Antonia Armas de Padron   +2 more
doaj   +6 more sources

Suppression of Cisplatin-Induced Vomiting by Cannabis sativa in Pigeons: Neurochemical Evidences

Frontiers in Pharmacology, 2018
Cannabis sativa (CS, family Cannabinaceae) has been reported for its anti-emetic activity against cancer chemotherapy-induced emesis in animal models and in clinics.
Ihsan Ullah, Ihsan Ullah, Fazal Subhan, Javaid Alam, Javaid Alam, Muhammad Shahid, Muhammad Ayaz   +6 more
doaj   +1 more source

The Effects of Propofol in the Area Postrema of Rats

Anesthesia & Analgesia, 2001
Propofol has an antiemetic effect that may be mediated by gamma-aminobutyric acid (GABA) influences on the serotonin system, the mechanism of which is not known. We used three techniques, immunohistochemistry, High Performance Liquid Chromatography, and electrophysiology, to define propofol's effects on the rat's brainstem.
D F, Cechetto, T, Diab, C J, Gibson, A W, Gelb   +3 more
openaire   +3 more sources

The ciliary neurotrophic factor induces Stat3 phosphorylation in distinctive cytotypes of organs involved in body metabolism: An immunohistochemical study

Journal of Anatomy, EarlyView.
p‐STAT3‐positive cells in metabolically relevant peripheral organs and tissues from mice administered with recombinant CNTF (0.3 mg/kg). Abstract Administration of ciliary neurotrophic factor (CNTF) reduces food intake and body weight in both humans and experimental animals, where it also ameliorates hyperglycemia, hyperinsulinemia, and dyslipidemia ...
Chiara Galli, Georgia Colleluori, Jessica Perugini, Edoardo Scopini, Ilenia Severi, Gaia Grandin, Antonio Giordano   +6 more
wiley   +1 more source

Area postrema excites and inhibits sympathetic-related neurons in rostral ventrolateral medulla in rabbit

, 1994
This study investigated the effects of area postrema stimulation on the activity of cardiovascular-related neurons in the rostral ventrolateral medulla and determined whether the effects were mediated by cell bodies.
C. G. Wilson, A. C. Bonham
core   +1 more source