Results 91 to 100 of about 3,042,026 (332)

Distinct metabolic profile according to the shape of the oral glucose tolerance test curve is related to whole glucose excursion: a cross-sectional study

BMC Endocrine Disorders, 2018
Background The shapes of the plasma glucose concentration curve during the oral glucose tolerance test are related to different metabolic risk profiles and future risk of type 2 DM.
Leonardo de Andrade Mesquita, Luciana Pavan Antoniolli, Giordano Fabricio Cittolin-Santos, Fernando Gerchman   +3 more
doaj   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

On splitting the area under curves II

Journal of Differential Equations, 1982
AbstractThis paper continues the author's work [3, S. Minsker, J. Differential Equations, 26, No. 3 (1977), 443–457.] on an area-splitting problem leading to the functional differential equation a′(a(x)) = a(x)x. This equation is dealt with by transforming it into the linear equation ψ′(x) = ψ(x + c), for which positive solutions on (−∞, −c) are sought.
openaire   +1 more source

Daptomycin area under the curve to minimum inhibitory concentration ratio by broth microdilution for predicting the outcome of vancomycin-resistant Enterococcus bloodstream infection

, 2022
Yu‐Chung Chuang, Hsin‐Yi Lin, Jann‐Tay Wang, Jia‐Ling Yang, Chi‐Ying Lin, Sung‐Hsi Huang, Yee‐Chun Chen, Shan‐Chwen Chang   +7 more
openalex   +1 more source

Vancomycin Area Under the Curve–Guided Dosing and Monitoring for Adult and Pediatric Patients With Suspected or Documented Serious Methicillin-Resistant Staphylococcus aureus Infections: Putting the Safety of Our Patients First [PDF]

, 2020
Thomas P. Lodise, George L. Drusano
openalex   +1 more source

Measuring the Discriminative Power of Rating Systems [PDF]

Assessing the discriminative power of rating systems is an important question to banks and to regulators. In this article we analyze the Cumulative Accuracy Profile (CAP) and the Receiver Operating Characteristic (ROC) which are both commonly used in ...
Engelmann, Bernd, Hayden, Evelyn, Tasche, Dirk   +2 more
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Hemoglobin A1c Risk Score for the Prediction of Coronary Artery Disease in Subjects with Angiographically Diagnosed Coronary Atherosclerosis

Cellular Physiology and Biochemistry, 2014
Objective: To develop a risk score by incorporating Hemoglobin A1c(HbA1c) with traditional risk factors for the prediction of coronary artery disease (CAD) in Chinese subjects.
En-Zhi Jia, Feng-Hui An, Zhao-Hong Chen, Li-Hua Li, Hong-Wei Mao, Zhao-Yang Li, Zhe Liu, Yan Gu, Tie-Bing Zhu, Lian-Sheng Wang, Chun-Jian Li, Wen-Zhu Ma, Zhi-Jian Yang   +12 more
doaj   +1 more source

Crop traits relevant for selecting potato genotypes adapted to low nitrogen availability [PDF]

, 2012
Canopy cover development was measured for 6 to 18 different potato varieties, under 3 different nitrogen regimes. This canopy cover development can be expressed in several paramaters.
Lammerts van Bueren, E.T., Struik, Paul, Tiemens-Hulscher, Marjolein   +2 more
core