Results 71 to 80 of about 128,871,322 (303)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Estimating the Area under a Receiver Operating Characteristic Curve For Repeated Measures Design [PDF]

The receiver operating characteristic (ROC) curve is widely used for diagnosing as well as for judging the discrimination ability of different statistical models.
Honghu Liu, Tongtong Wu
core  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Curve under construction, 2006

, 2006
Curve begins to take shape, with the Exchange Buildings visible in the background.
Hyde, Colin;
core   +1 more source

Degree-Based Similarity Indexes for Identifying Potential miRNA-Disease Associations

IEEE Access, 2020
Identifying disease-associated miRNAs is helpful to explore the pathogenesis of diseases. However, without foreknowledge of the experimentally valid disease-associated miRNAs information, the development of promising and affordable approaches for ...
Yajie Meng, Min Jin, Xianfang Tang, Junlin Xu   +3 more
doaj   +1 more source

On splitting the area under curves II

Journal of Differential Equations, 1982
AbstractThis paper continues the author's work [3, S. Minsker, J. Differential Equations, 26, No. 3 (1977), 443–457.] on an area-splitting problem leading to the functional differential equation a′(a(x)) = a(x)x. This equation is dealt with by transforming it into the linear equation ψ′(x) = ψ(x + c), for which positive solutions on (−∞, −c) are sought.
openaire   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Investigating sensitivity, specificity, and area under the curve of the Clinical COPD Questionnaire, COPD Assessment Test, and Modified Medical Research Council scale according to GOLD using St George's Respiratory Questionnaire cutoff 25 (and 20) as reference

International Journal of COPD, 2016
Ioanna G Tsiligianni,1,2 Harma J Alma,1,2 Corina de Jong,1,2 Danijel Jelusic,3 Michael Wittmann,3 Michael Schuler,4 Konrad Schultz,3 Boudewijn J Kollen,1 Thys van der Molen,1,2 Janwillem WH Kocks1,2 1Department of General Practice, 2GRIAC Research ...
Tsiligianni IG, Alma HJ, de Jong C, Jelusic D, Wittmann M, Schuler M, Schultz K, Kollen BJ, van der Molen T, Kocks JWH   +9 more
doaj  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

On splitting the area under curves

Journal of Differential Equations, 1977
AbstractTwo area-splitting problems involving real-valued functions of a real variable are investigated. The second of these is essentially equivalent to finding all functions a ϵ C1((0, r)) with 0 < a(x) < x which satisfy the functional differential equation a′ (a(x)) = a(x)x for x ϵ (0, r). All solutions analytic at x = 0 (and many which are not) are
openaire   +2 more sources