Results 91 to 100 of about 128,871,322 (303)

Area under the curve of immunosuppressants.

, 2016
Area under the curve of immunosuppressants.
Susanne Stampf (3387182), Stefan Schaub (93526), Karen Molyneux (3387176), Jonathan Barratt (3387179), Michael T. Koller (2735299), Min Jeong Kim (234956)   +5 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Area under the operating characteristics curve.

, 2015
Area under the operating characteristics curve.
Jian Liao (20886), Tingting Huang (496866), Xue Xiao (200270), Weilin Zhao (766615), Xiaoying Zhou (119401), Zhe Zhang (81603), Longde Lin (766616), Huixin Ming (759952), Weimin Ye (20887), Xiaoyun Zeng (698516), Yufeng Chen (560054), Guangwu Huang (300370), Yancheng Li (766617)   +12 more
core   +1 more source

Factors affecting free vancomycin concentration and target attainment of free area under the concentration-time curve

Journal of Pharmaceutical Health Care and Sciences
Background It has been reported that the protein binding rate of vancomycin (VCM) varies among individual patients. So, the authors investigated relevant factors that may affect free VCM concentration and target attainment of free area under the ...
Toshiharu Urakami, Yusuke Oka, Takashi Matono, Yosuke Aoki   +3 more
doaj   +1 more source

Distinct metabolic profile according to the shape of the oral glucose tolerance test curve is related to whole glucose excursion: a cross-sectional study

BMC Endocrine Disorders, 2018
Background The shapes of the plasma glucose concentration curve during the oral glucose tolerance test are related to different metabolic risk profiles and future risk of type 2 DM.
Leonardo de Andrade Mesquita, Luciana Pavan Antoniolli, Giordano Fabricio Cittolin-Santos, Fernando Gerchman   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Area under the Curve Greater Than z1.58 [PDF]

, 2021
FIGURE 6.4. Area under the curve greater than z = 1.58. (“Area under the Curve Greater than z1.58” by Judy Schmitt is licensed under CC BY-NC-SA 4.0.)https://irl.umsl.edu/oer-img/1061/thumbnail ...
Schmitt, Judy
core  

Testing the significance of crossover receiver operating characteristic curves in the presence of multiple markers

Journal of Biostatistics and Epidemiology, 2017
Background & Aim: In multivariate receiver operating characteristic (MROC) curve analysis, comparing two tests is usually done by means of area under the curve (AUC’s) and sensitivities.
Sameera Govindaraju Govindaraju, Vishnu Vardhan Rudravaram   +1 more
doaj