Results 101 to 110 of about 3,042,026 (332)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Automated Atrial Fibrillation Detection from Electrocardiogram [PDF]

, 2019
In this study, a novel Atrial Fibrillation (AFib) detection algorithm is presented based on Electrocardiography (ECG) signals. In particular, the spectrogram of ECG signal is used as an input to a Convolutional Neural Network (CNN) to classify normal and
Lu, Senbao
core   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Testing the significance of crossover receiver operating characteristic curves in the presence of multiple markers

Journal of Biostatistics and Epidemiology, 2017
Background & Aim: In multivariate receiver operating characteristic (MROC) curve analysis, comparing two tests is usually done by means of area under the curve (AUC’s) and sensitivities.
Sameera Govindaraju Govindaraju, Vishnu Vardhan Rudravaram   +1 more
doaj  

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

On splitting the area under curves

Journal of Differential Equations, 1977
AbstractTwo area-splitting problems involving real-valued functions of a real variable are investigated. The second of these is essentially equivalent to finding all functions a ϵ C1((0, r)) with 0 < a(x) < x which satisfy the functional differential equation a′ (a(x)) = a(x)x for x ϵ (0, r). All solutions analytic at x = 0 (and many which are not) are
openaire   +2 more sources

Integrals of life: tracking ecosystem spatial heterogeneity from space through the area under the curve of the parametric Rao's Q index

, 2023
Elisa Thouverai, Matteo Marcantonio, Jonathan Lenoir, Mariasole Galfré, Elisa Marchetto, Giovanni Bacaro, Roberto Cazzolla Gatti, Daniele Da Re, Michele Di Musciano, Reinhard Furrer, Marco Malavasi, Vítězslav Moudrý, Jakub Nowosad, Franco Pedrotti, Raffaele Pelorosso, Giovanna Pezzi, Carlo Ricotta, Sonia Silvestri, Petra Šímová, Enrico Tordoni, Michele Torresani, Giorgio Vacchiano, Piero Zannini, Duccio Rocchini   +23 more
openalex   +1 more source

Estimating the Area under a Receiver Operating Characteristic Curve For Repeated Measures Design [PDF]

The receiver operating characteristic (ROC) curve is widely used for diagnosing as well as for judging the discrimination ability of different statistical models.
Honghu Liu, Tongtong Wu
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Correlation between Cyclosporine Blood Levels and Area under Blood Concentration Time Curve in Iraqi Bone Marrow Transplant Patients Treated with Neoral® Oral Solution [PDF]

, 2020
Haidy A. Abass, Kawther F. Al-Tamimi, Duaa J. Al-Tamimi, Jaafar J. Ibraheem   +3 more
openalex   +1 more source