Results 191 to 200 of about 304,364 (248)

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Diagnostic value of systemic immune-inflammation index in differentiating testicular torsion from epididymo-orchitis based on symptom duration: A retrospective observational study. [PDF]

Medicine (Baltimore)
Demir M, Ördek E, Yağmur İ, Albayrak İH, Karadeniz MN, Şengel E.   +5 more
europepmc   +1 more source

Data‐Guided Photocatalysis: Supervised Machine Learning in Water Splitting and CO2 Conversion

Advanced Intelligent Discovery, EarlyView.
This review highlights recent advances in supervised machine learning (ML) for photocatalysis, emphasizing methods to optimize photocatalyst properties and design materials for solar‐driven water splitting and CO2 reduction. Key applications, challenges, and future directions are discussed, offering a practical framework for integrating ML into the ...
Paul Rossener Regonia, Christian Mark Pelicano   +1 more
wiley   +1 more source

Toward Predictable Nanomedicine: Current Forecasting Frameworks for Nanoparticle–Biology Interactions

Advanced Intelligent Discovery, EarlyView.
Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova, Michael Nicholls, Nicola Russo, Gueorgui Mihaylov, Konstantin Nikolic   +4 more
wiley   +1 more source

Serum-based BRAF V600E detection improves early diagnosis of papillary thyroid carcinoma: A prospective diagnostic accuracy study compared with ultrasound-guided cytology. [PDF]

Medicine (Baltimore)
Li Q, Lu Y, Li X, Jiang J, Wang X, Xu J, Zhang Q, Zhao L.   +7 more
europepmc   +1 more source

Characterization and Clinical Diagnostic Potential of IHRDEGs in Renal Interstitial Fibrosis: An Integrative Data Analysis and Model Construction Study. [PDF]

J Inflamm Res
Zhang J, Dang X, Dai E.
europepmc   +1 more source

Identification of risk factors and development of a predictive model for foetal growth restriction: a retrospective case-control study. [PDF]

Ann Med
Shao XF.
europepmc   +1 more source

Psychosocial Stress in the Chinese Community: Speech Analytics Through Linguistic and Acoustic Fusion Using Machine Learning. [PDF]

JMIR Biomed Eng
Chu AMY, Lam BSY, Tsang JTY, Tiwari A, Chan JNL, So MKP.   +5 more
europepmc   +1 more source

Feasibility and Psychometrics of a New Test Battery for Diagnosing Patients With Schizophrenia Spectrum Disorders. [PDF]

Cureus
Fichadia PA, Sung H, Kongala S, Weber D, Wang D, Leontieva L.   +5 more
europepmc   +1 more source

Evaluating Preclinical-to-Human Bioavailability Classification Using Smooth ROC Curve Estimation. [PDF]

CPT Pharmacometrics Syst Pharmacol
Erdoğan MS.
europepmc   +1 more source