Results 61 to 70 of about 352,956 (291)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Beach sand composition and provenance in a sector of the southwestern Mexican Pacific
Revista Mexicana de Ciencias Geológicas, 2014 Se analizó la textura, petrología y geoquímica de sedimentos arenosos de once playas del suroeste de México. El objetivo fue interpretar la procedencia de las arenas en términos del tamaño de grano, petrología y geoquímica y observar si el ambiente de ...
Arturo Carranza-Edwards +4 more
doaj
Revista Científica y Tecnológica UPSE, 2018 Una solución adecuada para la recuperación de una playa, es regenerarla mediante un Relleno Hidráulico; en el caso de la playa de San Lorenzo (Salinas, provincia de Santa Elena), se propone el uso de una Draga de Succión en Marcha de 1500m3, para la ...
Humberto Guerrero Herrera +2 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
UNA COMPARACIÓN DE RENDIMIENTO ENTRE ORACLE Y MONGODB
Ciencia e Ingeniería Neogranadina, 2016 Este trabajo tuvo por objetivo evaluar la arena (A), el carbón activado (CA) y la zeolita (Z) como materiales filtrantes para valorar su efecto en reutilización para agricultura de aguas residuales tratadas de un ambiente árido. Para esto se construyeron
Francisco Javier Moreno Arboleda +2 more
doaj
Demokratiets stilling i Europa – hva gjør EU? Hva er Norges rolle?
Internasjonal PolitikkDenne artikkelen gir en kort oversikt over demokratiets stilling i Europa og hva dette sier om Norge og dets rolle, siden Norge er så sterkt påvirket av hva som skjer i Europa. Vi gir først en oversikt over demokratiets stilling i Europa, med fokus på EU,
John Erik Fossum, Trym Fjørtoft
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source