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Preclinical evaluation of two phylogenetically distant arenavirus vectors for the development of novel immunotherapeutic combination strategies for cancer treatment. [PDF]

J Immunother Cancer
Raguz J, Pinto C, Pölzlbauer T, Habbeddine M, Rosskopf S, Strauß J, Just V, Schmidt S, Bidet Huang K, Stemeseder F, Schippers T, Stewart E, Jez J, Berraondo P, Orlinger KK, Lauterbach H.   +15 more
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Structural insight into arenavirus replication machinery

Nature, 2020
Arenaviruses can cause severe haemorrhagic fever and neurological diseases in humans and other animals, exemplified by Lassa mammarenavirus, Machupo mammarenavirus and lymphocytic choriomeningitis virus, posing great threats to public health1-4. These viruses encode a large multi-domain RNA-dependent RNA polymerase for transcription and replication of ...
Ruchao Peng, Xichen Bao, Jianxun Qi
exaly   +3 more sources

Arenavirus Gene Structure and Organization

1987
For rhabdoviruses, paramyxoviruses, orthomyxoviruses, and some members of the Bunyaviridae, all the proteins are translated from the viral-complementary RNA sequence. This is in contrast to the genetic strategy of picornaviruses, caliciviruses, coronaviruses, togaviruses, flaviviruses, and retroviruses, whose proteins are all translated from the viral ...
D H, Bishop, D D, Auperin
openaire   +2 more sources

Structural components of the arenavirus Pichinde

Journal of Virology, 1977
Purified Pichinde virions grown in monolayers of BHK-21 cells were found to contain three major species of virion proteins as described previously (Ramos et al., J. Virol. 10:661-667, 1972). Two of the proteins were glycosylated (G1, molecular weight = 64,000; G2, molecular weight = 38,000) and were present in similar proportions on the outer surface ...
A C, Vezza, G P, Gard, R W, Compans, D H, Bishop   +3 more
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Arenavirus extinction through lethal mutagenesis

Virus Research, 2005
Viral hemorrhagic fevers represent serious human public health problems causing devastating and often lethal disease. Several hemorrhagic fevers are caused by arenaviruses including Lassa fever virus (LFV) and the South American viral hemorrhagic fevers (SAHF).
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Development of Recombinant Arenavirus-Based Vaccines

2017
The development of arenavirus reverse genetics has provided investigators with a novel and powerful approach for the investigation of the arenavirus molecular and cell biology. The use of cell-based minigenome systems has allowed examining the cis- and trans-acting factors involved in arenavirus replication and transcription, and the identification of ...
Luis, Martínez-Sobrido, Juan Carlos, de la Torre   +1 more
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Mapping Arenavirus Genes Causing Virulence

1987
The reassortment of genetic information from RNA viruses with segmented genomes, i. e., Arenaviridae, Bunyaviridae, Orthomyxoviridae, and Reoviridae families, can occur within cells infected by two different viral strains from the same family (COmpans etal. 1981; FIelds and GReene 1982; WEbster etal. 1982; Palese 1984).
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Pathology and Pathogenesis of Arenavirus Infections

1987
In systemic virus infections, such as the arenavirus hemorrhagic fevers, pathologic and histopathologic examinations often contribute to the initial understanding of the nature of the disease, but definition of pathogenic mechanisms requires the addition of complementary techniques and experimental approaches – usually in animal models. The commonality
D H, Walker, F A, Murphy
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