Results 1 to 10 of about 2,533 (119)

Laboratory acquired infection by the virus SP H 114202 (Arenavirus: Arenaviridae): clinical and laboratory findings [PDF]

Revista Do Instituto De Medicina Tropical De Sao Paulo, 1993
Here in is described the clinical and laboratorial findings of a laboratory-acquired infection caused by the virus SP H 114202 (Arenavirus, family Arenaviridae) a recently discovered agent responsible for a viral hemorrhagic fever. The patient was sick for 13 days.
Vasconcelos Pfc, A P Travassos Da Rosa, Robert Tesh   +2 more
exaly   +5 more sources

Vaccine Candidates against Arenavirus Infections

Vaccines, 2023
The viral family Arenaviridae contains several members that cause severe, and often lethal, diseases in humans. Several highly pathogenic arenaviruses are classified as Risk Group 4 agents and must be handled in the highest biological containment ...
Takeshi Saito, Rachel A. Reyna, Satoshi Taniguchi, Kirsten Littlefield, Slobodan Paessler, Junki Maruyama   +5 more
doaj   +1 more source

Factors affecting RIG-I-Like receptors activation - New research direction for viral hemorrhagic fevers

Frontiers in Immunology, 2022
Viral hemorrhagic fever (VHF) is a term referring to a group of life-threatening infections caused by several virus families (Arenaviridae, Bunyaviridae, Filoviridae and Flaviviridae).
Paulina Małkowska, Paulina Małkowska, Paulina Niedźwiedzka-Rystwej   +2 more
doaj   +1 more source

Combination of highly antigenic nucleoproteins to inaugurate a cross-reactive next generation vaccine candidate against Arenaviridae family

Heliyon, 2021
Arenaviral infections often result lethal hemorrhagic fevers, affecting primarily in African and South American regions. To date, there is no FDA-approved licensed vaccine against arenaviruses and treatments have been limited to supportive therapy. Hence,
Kazi Faizul Azim, Tahera Lasker, Rahima Akter, Mantasha Mahmud Hia, Omar Faruk Bhuiyan, Mahmudul Hasan, Md Nazmul Hossain   +6 more
doaj   +1 more source

Experimental Infection of the Cane MouseZygodontomys brevicauda(Family Muridae) with Guanarito Virus (Arenaviridae), the Etiologic Agent of Venezuelan Hemorrhagic Fever [PDF]

The Journal of Infectious Diseases, 1999
Chronic infections in specific rodents appear to be crucial to the long-term persistence of arenaviruses in nature. The cane mouse, Zygodontomys brevicauda, is a natural host of Guanarito virus (family Arenaviridae), the etiologic agent of Venezuelan hemorrhagic fever.
C F, Fulhorst, T G, Ksiazek, C J, Peters, R B, Tesh   +3 more
openaire   +2 more sources

Modulation of the Aryl Hydrocarbon Receptor Signaling Pathway Impacts on Junín Virus Replication

Viruses, 2023
Junín virus (JUNV), a member of the family Arenaviridae, is the etiological agent of the Argentine hemorrhagic fever, an endemic disease in the rural region of Argentina lacking a specific chemotherapy.
Miguel Angel Pelaez, María Florencia Torti, Aaron Ezequiel Alvarez De Lauro, Agostina Belén Marquez, Federico Giovannoni, Elsa Beatriz Damonte, Cybele Carina García   +6 more
doaj   +1 more source

A Lassa virus mRNA vaccine confers protection but does not require neutralizing antibody in a guinea pig model of infection

Nature Communications, 2023
Lassa virus is a member of the Arenaviridae family, which causes human infections ranging from asymptomatic to severe hemorrhagic disease with a high case fatality rate.
Adam J. Ronk, Nicole M. Lloyd, Min Zhang, Caroline Atyeo, Hailee R. Perrett, Chad E. Mire, Kathryn M. Hastie, Rogier W. Sanders, Philip J. M. Brouwer, Erica Olmann Saphire, Andrew B. Ward, Thomas G. Ksiazek, Juan Carlos Alvarez Moreno, Harshwardhan M. Thaker, Galit Alter, Sunny Himansu, Andrea Carfi, Alexander Bukreyev   +17 more
doaj   +1 more source

Novel Dihydroorotate Dehydrogenase Inhibitors with Potent Interferon-Independent Antiviral Activity against Mammarenaviruses In Vitro

Viruses, 2020
Mammarenaviruses cause chronic infections in rodents, which are their predominant natural hosts. Human infection with some of these viruses causes high-consequence disease, posing significant issues in public health.
Yu-Jin Kim, Beatrice Cubitt, Yingyun Cai, Jens H. Kuhn, Daniel Vitt, Hella Kohlhof, Juan C. de la Torre   +6 more
doaj   +1 more source

Imported Lassa Fever, Pennsylvania, USA, 2010

Emerging Infectious Diseases, 2010
We report a case of Lassa fever in a US traveler who visited rural Liberia, became ill while in country, sought medical care upon return to the United States, and subsequently had his illness laboratory confirmed.
Valerianna Amorosa, Adam MacNeil, Ryan McConnell, Ami Patel, Katherine E. Dillon, Keith Hamilton, Bobbie Rae Erickson, Shelley Campbell, Barbara Knust, Deborah L. Cannon, David M. Miller, Craig Manning, Pierre E. Rollin, Stuart T. Nichol   +13 more
doaj   +1 more source

Differential Immune Responses to Hemorrhagic Fever-Causing Arenaviruses

Vaccines, 2019
The family Arenaviridae contains several pathogens of major clinical importance. The Old World (OW) arenavirus Lassa virus is endemic in West Africa and is estimated to cause up to 300,000 infections each year.
Emily Mantlo, Slobodan Paessler, Cheng Huang   +2 more
doaj   +1 more source