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Vaccine Candidates against Arenavirus Infections

Vaccines, 2023
The viral family Arenaviridae contains several members that cause severe, and often lethal, diseases in humans. Several highly pathogenic arenaviruses are classified as Risk Group 4 agents and must be handled in the highest biological containment ...
Takeshi Saito, Rachel A. Reyna, Satoshi Taniguchi, Kirsten Littlefield, Slobodan Paessler, Junki Maruyama   +5 more
doaj   +3 more sources

Effect of the AHR Inhibitor CH223191 as an Adjunct Treatment for Mammarenavirus Infections. [PDF]

Int J Mol Sci
The family Arenaviridae encompasses zoonotic, rodent-borne pathogens (e.g., Lassa, Machupo, and Junín viruses) that cause severe viral hemorrhagic fevers with high case fatality rates.
Pelaez MA, Westover JB, Scharton D, García CC, Gowen BB.   +4 more
europepmc   +3 more sources

A Lassa virus mRNA vaccine confers protection but does not require neutralizing antibody in a guinea pig model of infection

Nature Communications, 2023
Lassa virus is a member of the Arenaviridae family, which causes human infections ranging from asymptomatic to severe hemorrhagic disease with a high case fatality rate.
Adam J. Ronk, Nicole M. Lloyd, Min Zhang, Caroline Atyeo, Hailee R. Perrett, Chad E. Mire, Kathryn M. Hastie, Rogier W. Sanders, Philip J. M. Brouwer, Erica Olmann Saphire, Andrew B. Ward, Thomas G. Ksiazek, Juan Carlos Alvarez Moreno, Harshwardhan M. Thaker, Galit Alter, Sunny Himansu, Andrea Carfi, Alexander Bukreyev   +17 more
doaj   +3 more sources

Differential Immune Responses to Hemorrhagic Fever-Causing Arenaviruses

Vaccines, 2019
The family Arenaviridae contains several pathogens of major clinical importance. The Old World (OW) arenavirus Lassa virus is endemic in West Africa and is estimated to cause up to 300,000 infections each year.
Emily Mantlo, Slobodan Paessler, Cheng Huang   +2 more
doaj   +3 more sources

Modulation of the Aryl Hydrocarbon Receptor Signaling Pathway Impacts on Junín Virus Replication [PDF]

Viruses, 2023
Junín virus (JUNV), a member of the family Arenaviridae, is the etiological agent of the Argentine hemorrhagic fever, an endemic disease in the rural region of Argentina lacking a specific chemotherapy.
Miguel Angel Pelaez, María Florencia Torti, Aaron Ezequiel Alvarez De Lauro, Agostina Belén Marquez, Federico Giovannoni, Elsa Beatriz Damonte, Cybele Carina García   +6 more
doaj   +3 more sources

Combination of highly antigenic nucleoproteins to inaugurate a cross-reactive next generation vaccine candidate against Arenaviridae family

Heliyon, 2021
Arenaviral infections often result lethal hemorrhagic fevers, affecting primarily in African and South American regions. To date, there is no FDA-approved licensed vaccine against arenaviruses and treatments have been limited to supportive therapy. Hence,
Kazi Faizul Azim, Tahera Lasker, Rahima Akter, Mantasha Mahmud Hia, Omar Faruk Bhuiyan, Mahmudul Hasan, Md Nazmul Hossain   +6 more
doaj   +2 more sources

Experimental Infection of the Cane MouseZygodontomys brevicauda(Family Muridae) with Guanarito Virus (Arenaviridae), the Etiologic Agent of Venezuelan Hemorrhagic Fever [PDF]

The Journal of Infectious Diseases, 1999
Chronic infections in specific rodents appear to be crucial to the long-term persistence of arenaviruses in nature. The cane mouse, Zygodontomys brevicauda, is a natural host of Guanarito virus (family Arenaviridae), the etiologic agent of Venezuelan hemorrhagic fever.
C F, Fulhorst, T G, Ksiazek, C J, Peters, R B, Tesh   +3 more
openaire   +3 more sources

When zoonosis mimics autoimmunity: arenavirus spillover, gut dysbiosis, and the case for community-level early warning systems. [PDF]

Ann Med Surg (Lond)
Rodent-borne viruses continue to represent a major, but often underestimated, source of emerging human infection, particularly in ecologically unstable and resource-limited settings.
Sanan A, Tanveer M, Batool ST, Sadat SH.
europepmc   +2 more sources

Factors affecting RIG-I-Like receptors activation - New research direction for viral hemorrhagic fevers

Frontiers in Immunology, 2022
Viral hemorrhagic fever (VHF) is a term referring to a group of life-threatening infections caused by several virus families (Arenaviridae, Bunyaviridae, Filoviridae and Flaviviridae).
Paulina Małkowska, Paulina Małkowska, Paulina Niedźwiedzka-Rystwej   +2 more
doaj   +2 more sources

Ebola Virus Disease: Uniquely Challenging Among the Viral Hemorrhagic Fevers. [PDF]

Open Forum Infect Dis
Viral hemorrhagic fever is a severe illness characterized by constitutional signs and symptoms accompanied by coagulopathy, shock, and multiorgan failure caused by dozens of enveloped RNA viruses spanning 6 viral families: Flaviviridae, Arenaviridae ...
Matson MJ, Chertow DS, Munster VJ.
europepmc   +2 more sources