Results 21 to 30 of about 3,575 (156)
Lassa fever vaccine candidates: A scoping review of vaccine clinical trials
Tropical Medicine &International Health, Volume 28, Issue 6, Page 420-431, June 2023., 2023 Abstract Objective Lassa fever (LF) is caused by a viral pathogen with pandemic potential. LF vaccines have the potential to prevent significant disease in individuals at risk of infection, but no such vaccine has been licensed or authorised for use thus far.
Giorgia Sulis +2 more
wiley +1 more source
Differential Immune Responses to Hemorrhagic Fever-Causing Arenaviruses
Vaccines, 2019 The family Arenaviridae contains several pathogens of major clinical importance. The Old World (OW) arenavirus Lassa virus is endemic in West Africa and is estimated to cause up to 300,000 infections each year.
Emily Mantlo +2 more
doaj +1 more source
VIPR: a probabilistic algorithm for analysis of microbial detection microarrays [PDF]
, 2010 Background All infectious disease oriented clinical diagnostic assays in use today focus on detecting the presence of a single, well defined target agent or a set of agents.
Adam F Allred +6 more
core +2 more sources
Journal of Applied Toxicology, Volume 43, Issue 5, Page 719-733, May 2023., 2023 Abstract MV‐LASV is an investigational measles Schwarz‐based vaccine for the prevention of Lassa fever. A repeated‐dose toxicity study in cynomolgus macaques was performed to assess the biodistribution and local and systemic toxicological effects. Monkeys received three immunizations of MV‐LASV or saline intramuscularly with a 2‐week interval.
Sabrina Schrauf +6 more
wiley +1 more source
Effective oral favipiravir (T-705) therapy initiated after the onset of clinical disease in a model of arenavirus hemorrhagic Fever. [PDF]
PLoS Neglected Tropical Diseases, 2011 Lassa and Junín viruses are the most prominent members of the Arenaviridae family of viruses that cause viral hemorrhagic fever syndromes Lassa fever and Argentine hemorrhagic fever, respectively.
Michelle Mendenhall +6 more
doaj +1 more source
Prevalence of inclusion body disease and associated comorbidity in captive collections of boid and pythonid snakes in Belgium [PDF]
, 2020 Inclusion body disease (IBD) is caused by reptarenaviruses and constitutes one of the most notorious viral diseases in snakes. Although central nervous system disease and various other clinical signs have been attributed to IBD in boid and pythonid ...
Hellebuyck, Tom +3 more
core +1 more source
Health Science Reports, Volume 6, Issue 1, January 2023., 2023 Abstract Crimean‐Congo hemorrhagic fever (CCHF) is an infection caused by a tick‐borne virus (genus: Nairovirus, family: Bunyaviridae). The most important vector for CCHF is the ixodid tick. Along with tick bite, direct contact with the virus‐affected animal is responsible for its spread. Pakistan witnessed its first case of CCHF in 1976 and has been a
Shehroze Tabassum +5 more
wiley +1 more source
Lassa fever. Part 1. Etiology, epidemiology and clinical manifestations
Инфекция и иммунитет, 2022 Lassa fever is a natural focal disease dangerous for humans. In the larger part of sub-Saharan West Africa 37.7 million people in 14 countries live in areas where living conditions are suitable for zoonotic transmission of the virus from secretions of ...
Elena I. Kazachinskaia +3 more
doaj +1 more source
Protease inhibitors targeting coronavirus and filovirus entry. [PDF]
, 2015 In order to gain entry into cells, diverse viruses, including Ebola virus, SARS-coronavirus and the emerging MERS-coronavirus, depend on activation of their envelope glycoproteins by host cell proteases.
Agudelo, Juliet +10 more
core +1 more source
A little less aggregation a little more replication: Viral manipulation of stress granules
WIREs RNA, Volume 14, Issue 1, January/February 2023., 2023 Viruses depend entirely on host machinery and therefore aim to conquer the host and defeat its defenses to co‐opt its resources for its own replication. Improved understanding of how viruses counteract host immune responses such as stress granule assembly, detailed here, will inform future antiviral therapeutic strategies.
Matthew J. Brownsword, Nicolas Locker
wiley +1 more source