Results 41 to 50 of about 3,575 (156)

Dendritic Cells (DCs) as "Fire Accelerants" of Hantaviral Pathogenesis [PDF]

, 2019
Hantaviruses are widespread zoonotic pathogens found around the globe. Depending on their geographical location, hantaviruses can cause two human syndromes, haemorrhagic fever with renal syndrome (HFRS) or hantavirus pulmonary syndrome (HPS).
Raftery, Martin J., Schönrich, Günther
core   +1 more source

Systems immunology of transcriptional responses to viral infection identifies conserved antiviral pathways across macaques and humans

Cell Reports
Summary: Viral pandemics and epidemics pose a significant global threat. While macaque models of viral disease are routinely used, it remains unclear how conserved antiviral responses are between macaques and humans.
Kalani Ratnasiri, Hong Zheng, Jiaying Toh, Zhiyuan Yao, Veronica Duran, Michele Donato, Mario Roederer, Megha Kamath, John-Paul M. Todd, Matthew Gagne, Kathryn E. Foulds, Joseph R. Francica, Kizzmekia S. Corbett, Daniel C. Douek, Robert A. Seder, Shirit Einav, Catherine A. Blish, Purvesh Khatri   +17 more
doaj   +1 more source

Serological Assays Based on Recombinant Viral Proteins for the Diagnosis of Arenavirus Hemorrhagic Fevers

Viruses, 2012
The family Arenaviridae, genus Arenavirus, consists of two phylogenetically independent groups: Old World (OW) and New World (NW) complexes. The Lassa and Lujo viruses in the OW complex and the Guanarito, Junin, Machupo, Sabia, and Chapare viruses in the
Masayuki Saijo, Shigeru Morikawa, Tomoki Yoshikawa, Hideki Tani, Shuetsu Fukushi   +4 more
doaj   +1 more source

Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5 [PDF]

, 2011
The 5'-cap-structures of higher eukaryote mRNAs are ribose 2'-O-methylated. Likewise, a number of viruses replicating in the cytoplasm of eukayotes have evolved 2'-O-methyltransferases to modify autonomously their mRNAs.
A Ghosh, A Nomoto, A Pichlmair, AM Waterhouse, B Morin, Benjamin W Neuman, BS Schnierle, Burkhard Ludewig, CA Janeway Jr., DJ Hui, E Decroly, EJ Snijder, F Terenzi, G Bocharov, G Uzé, H Hemmi, H Kato, H Zhou, J Reguera, JK Roth-Cross, John Ziebuhr, K Bryson, K Karikó, KK Eriksson, KM Rose, Kristy J Szretter, L Cervantes-Barragan, L Cervantes-Barragán, L Gitlin, Luisa Cervantes-Barragan, M Bouvet, M Feder, M Schlee, Matthias Habjan, Michael S Diamond, O Haller, O Le Gall, O Takeuchi, R Gosert, R Züst, Reinhard Maier, Roland Züst, S Daffis, S Shuman, S Wünschmann, SR Nallagatla, SR Nallagatla, Stuart G Siddell, Susan C Baker, V Hornung, V Thiel, Volker Thiel, Winfried Barchet, Y Chen, YM Loo, YM Loo   +55 more
core   +1 more source

Production of CXC and CC chemokines by human antigen-presenting cells in response to Lassa virus or closely related immunogenic viruses, and in cynomolgus monkeys with lassa fever. [PDF]

, 2014
International audienceThe pathogenesis of Lassa fever (LF), a hemorrhagic fever endemic to West Africa, remains unclear. We previously compared Lassa virus (LASV) with its genetically close, but nonpathogenic homolog Mopeia virus (MOPV) and demonstrated ...
A Mantovani, A Wack, B Moser, C Pythoud, C-L Lin, D Cook, D Pannetier, D Pannetier, D Whiting, DD Pinschewer, DD Taub, DD Taub, DD Taub, Delphine Pannetier, DH Walker, DH Walker, F Castellino, H Sung Jung, H Wulff, IS Lukashevich, J ter Meulen, J ter Meulen, JB McCormick, JB McCormick, JE Christensen, JF Foley, JH Dufour, JR Groom, KM Hastie, KM Johnson, L Hensley, L Martinez-Sobrido, L Martinez-Sobrido, LL Xu, M Habjan, M Inngjerdingen, M Liu, M Loetscher, M Macal, M Perez, M Russier, M-F Hsieh, Marion Russier, MD Bowen, MM Djavani, MP Kiley, N Sogoba, O Lenz, R Lande, S Baize, S Baize, S Baize, S Deshmane, S Günther, S Mahanty, S Mahanty, S Malhotra, SL Ruo, Stéphanie Reynard, Sylvain Baize, T Strecker, Thomas Geisbert, TI Cornu, TJ Schall, W Cao, WWSI Rodrigo, X Carnec, X Qi, Xavier Carnec   +68 more
core   +5 more sources

Lassa Virus Infection of Primary Human Airway Epithelial Cells

Viruses
Lassa mammarenavirus (LASV), a member of the family Arenaviridae, is a highly pathogenic virus capable of causing severe systemic infections in humans.
Helena Müller-Kräuter, Sarah Katharina Fehling, Lucie Sauerhering, Birthe Ehlert, Janine Koepke, Juliane Schilling, Mikhail Matrosovich, Andrea Maisner, Thomas Strecker   +8 more
doaj   +1 more source

Antibodies to the Glycoprotein GP2 Subunit Cross-React between Old and New World Arenaviruses

mSphere, 2018
Arenaviruses pose a major public health threat and cause numerous infections in humans each year. Although most viruses belonging to this family do not cause disease in humans, some arenaviruses, such as Lassa virus and Machupo virus, are the etiological
Fatima Amanat, James Duehr, Lisa Oestereich, Kathryn M. Hastie, Erica Ollmann Saphire, Florian Krammer   +5 more
doaj   +1 more source

False positives complicate ancient pathogen identifications using high-throughput shotgun sequencing [PDF]

, 2014
Background: Identification of historic pathogens is challenging since false positives and negatives are a serious risk. Environmental non-pathogenic contaminants are ubiquitous.
Campana, Michael G, Robles García, Nelly, Rühli, Frank J, Tuross, Noreen   +3 more
core   +3 more sources

The Adaptive Immune Response against Bunyavirales

Viruses
The Bunyavirales order includes at least fourteen families with diverse but related viruses, which are transmitted to vertebrate hosts by arthropod or rodent vectors.
Reem Alatrash, Bobby Brooke Herrera
doaj   +1 more source

Arenavirus Stable Signal Peptide Is the Keystone Subunit for Glycoprotein Complex Organization

mBio, 2014
The rodent arenavirus glycoprotein complex encodes a stable signal peptide (SSP) that is an essential structural component of mature virions. The SSP, GP1, and GP2 subunits of the trimeric glycoprotein complex noncovalently interact to stud the surface ...
Lydia H. Bederka, Cyrille J. Bonhomme, Emily L. Ling, Michael J. Buchmeier   +3 more
doaj   +1 more source