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Pathogenesis of Lassa Fever [PDF]

Viruses, 2012
Lassa virus, an Old World arenavirus (family Arenaviridae), is the etiological agent of Lassa fever, a severe human disease that is reported in more than 100,000 patients annually in the endemic regions of West Africa with mortality rates for ...
David H. Walker, Nadezhda E. Yun
doaj   +4 more sources

Lassa fever vaccine

Expert Review of Vaccines, 2004
Lassa fever remains a serious challenge to public health in West Africa threatening both local residents in rural areas and those who serve them, particularly medical care providers. Given the ecology of the rodent host and conditions in the endemic area, a vaccine is mandatory for control.
S P Fisher-Hoch, Joseph B Mccormick
exaly   +3 more sources

Land use gradients drive spatial variation in Lassa fever host communities in the Eastern Province of Sierra Leone [PDF]

Journal of Animal Ecology, Volume 95, Issue 2, Page 296-312, February 2026.
As West Africa urbanises, the risk of Lassa fever may paradoxically decrease. We found the invasive house mouse, a dominant urban species, outcompetes and displaces the primary Lassa virus host. Considering these species interactions is critical for accurately predicting future zoonotic disease patterns.
David Simons, Rory Gibb, Umaru Bangura, Dianah Sondufu, Joyce Lamin, James Koninga, Momoh Foday, Mike Dawson, Joseph Lahai, Rashid Ansumana, Elisabeth Fichet‐Calvet, Deborah Watson‐Jones, Richard Kock, Kate E. Jones   +13 more
wiley   +2 more sources

Establishment of a Lassa Fever Specimen Biobank in Nigeria. [PDF]

Am J Trop Med Hyg
Despite being a dangerous disease found across West Africa, with occasional cases imported elsewhere, few medical countermeasures for Lassa fever are available, with no vaccine or validated treatment, and limited regulatory-approved diagnostics ...
Owhin, Sampson, Somiari, Stella, Etafo, Johnson, Ireneh, Ronke, Bausch, Daniel G, Adedosu, Nelson A, Fonkeng, Fritz, Abejegah, Chukwuyem, El Idrissi, Imane, Fransman, Warren, Kelly-Cirino, Cassandra, Vessière, Aurélia, Chi, Hanesh F, Olufunke, Gbenga-Ayeni Bosede, Agogo, Emmanuel, Emperador, Devy M   +15 more
core   +2 more sources

Lassa Fever in Travelers from West Africa, 1969–2016

Emerging Infectious Diseases, 2019
Lassa virus is a rodentborne arenavirus responsible for human cases of Lassa fever, a viral hemorrhagic fever, in West Africa and in travelers arriving to non–Lassa-endemic countries from West Africa.
Aaron Kofman, Mary J. Choi, Pierre E. Rollin   +2 more
doaj   +2 more sources

Current perspectives on vaccines and therapeutics for Lassa Fever [PDF]

Virol J
Lassa virus, the cause of deadly Lassa fever, is endemic in West Africa, where thousands of cases occur on an annual basis. Nigeria continues to report increasingly severe outbreaks of Lassa Fever each year and there are currently no approved vaccines or
David Safronetz, Derek R. Stein, Bryce M. Warner   +2 more
core   +3 more sources

Sensorineural hearing loss in Lassa fever: two case reports

Journal of Medical Case Reports, 2009
Introduction Lassa fever is an acute arena viral haemorrhagic fever with varied neurological sequelae. Sensorineural hearing loss is one of the rare complications which occur usually during the convalescent stage of the infection.
Okokhere Peter O, Ibekwe Titus S, Akpede George O   +2 more
doaj   +2 more sources

Lassa fever in West African sub-region: an overview [PDF]

Journal of Vector Borne Diseases, 2007
Lassa fever is an acute viral zoonotic illness caused by Lassa virus, an arenavirus known to beresponsible for a severe haemorrhagic fever characterised by fever, muscle aches, sore throat, nausea,vomiting and, chest and abdominal pain.
O. Ogbu, E. Ajuluchukwu, C.J. Uneke
doaj   +1 more source

Assessment of knowledge on Lassa fever disease among caregivers presenting to a tertiary Institution in a Lassa fever endemic region, Southeast Nigeria

Nigerian Journal of Paediatrics, 2022
Background: Lassa fever disease is an infectious disease with high case fatality occurring in countries in West, Central, and East Africa. It is endemic in Nigeria and Ebonyi State, Southeast Nigeria.
Maria-lauretta Chito Orji, Dorathy Chinwe Obu, Uzoma Vivian Asiegbu   +2 more
doaj   +3 more sources

Space-Time Trends in Lassa Fever in Sierra Leone by ELISA Serostatus, 2012–2019

Microorganisms, 2021
Lassa fever (LF) is a viral hemorrhagic disease found in Sub-Saharan Africa and is responsible for up to 300,000 cases and 5000 deaths annually. LF is highly endemic in Sierra Leone, particularly in its Eastern Province.
Jeffrey G. Shaffer, John S. Schieffelin, Mambu Momoh, Augustine Goba, Lansana Kanneh, Foday Alhasan, Michael Gbakie, Emily J. Engel, Nell G. Bond, Jessica N. Hartnett, Diana K. S. Nelson, Duane J. Bush, Matthew L. Boisen, Megan L. Heinrich, Megan M. Rowland, Luis M. Branco, Robert J. Samuels, Robert F. Garry, Donald S. Grant, the Viral Hemorrhagic Fever Consortium   +19 more
doaj   +1 more source