Results 41 to 50 of about 9,289 (204)

Time to reconsider the role of ribavirin in Lassa fever [PDF]

, 2021
Ribavirin is the only available Lassa fever treatment. The rationale for using ribavirin is based on one clinical study conducted in the early 1980s. However, reanalysis of previous unpublished data reveals that ribavirin may actually be harmful in some ...
Vincent Cheng, Tansy Edwards, Piero Olliaro, Sterne, Jonathan, Cheng, Vincent, Horby, Peter, Cheng, Hung-Yuan, Alex Paddy Salam, Salam, Alex Paddy, Edwards, Tansy, Peter Horby, Jonathan Sterne, Olliaro, Piero   +12 more
core   +1 more source

Use of Favipiravir to Treat Lassa Virus Infection in Macaques

Emerging Infectious Diseases, 2018
Lassa virus, the cause of Lassa fever in humans, is endemic to West Africa. Treatment of Lassa fever is primarily supportive, although ribavirin has shown limited efficacy if administered early during infection.
Kyle Rosenke, Heinz Feldmann, Jonna B. Westover, Patrick William Hanley, Cynthia Martellaro, Friederike Feldmann, Greg Saturday, Jamie Lovaglio, Dana P. Scott, Yousuke Furuta, Takashi Komeno, Brian B. Gowen, David Safronetz   +12 more
doaj   +1 more source

Widespread SARS‐CoV‐2 Transmission Despite Limited Reported Cases and Clinical Disease: Exploring the Role of Pre‐Existing Humoral Immunity to SARS‐CoV‐2 in Eastern Sierra Leone

Immunity, Inflammation and Disease, Volume 14, Issue 5, May 2026.
ABSTRACT Background Since December 2019, SARS‐CoV‐2 has infected over 700 million people and caused > 7 million deaths. While much of the global north was severely affected, sub‐Saharan Africa was relatively spared. Possible reasons include a younger population, fewer comorbidities, and pre‐existing immunity.
Robert J. Samuels, Nell G. Bond, Ibrahim Sumah, Donald S. Grant, Mohamed S. Kamara, Lydia Bazzano, Camilo Fernandez, Rodrigo Borrega, Sruti Chandra, Celia R. Glezer, John S. Schieffelin, Troy D. Moon   +11 more
wiley   +1 more source

Prevalence and risk factors of Lassa seropositivity in inhabitants of the forest region of Guinea: a cross-sectional study.

, 2009
BACKGROUND: Lassa fever is a viral hemorrhagic fever endemic in West Africa. The reservoir host of the virus is a multimammate rat, Mastomys natalensis.
Fichet-Calvet, Elisabeth, Elisabeth Fichet-Calvet, Philippe J Guerin, Magassouba, N'Faly, Koulemou, K, Lewis, R, Kekoura Koulemou, Rebecca F Grais, Guerin, Philippe J, Rosamund Lewis, Grais, Rebecca F., Guerin, Philippe J., Fichet-Calvet, E, Solen Kernéis, Grais, RF, Lamine Koivogui, Guerin, PJ, Philippe J. Guerin, N'Faly Magassouba, Grais, Rebecca F, Magassouba, N, Kernéis, Solen, Koivogui, Lamine, Lewis, Rosamund, Kernéis, S, Rebecca F. Grais, Koulemou, Kekoura, Aplogan, Aristide, Koivogui, L, Aplogan, A, Aristide Aplogan   +30 more
core   +1 more source

Descriptive epidemiology of Lassa fever, its trend, seasonality, and mortality predictors in Ebonyi State, South- East, Nigeria, 2018—2022

BMC Public Health
Background Nigeria is an epicenter for Lassa fever. Ebonyi state is located in the South-Eastern region of Nigeria where a high burden of Lassa fever has been reported.
Adanna Ezenwa-Ahanene, Adetokunbo T. Salawu, Ayo S. Adebowale   +2 more
doaj   +1 more source

Effectiveness of Yoruba language radio jingles in promoting knowledge, attitude and practices regarding Lassa fever among women in Ondo state, Nigeria

Journal of Public Health in Africa, 2020
Background: Lassa fever is one of the known Neglected Tropical Diseases (NTDs) that plague some states in Nigeria. Radio jingles in indigenous language have been adopted as a veritable risk communication approach to promote public knowledge in the bid to
Charity Ben-Enukora, Olushola Oyero, Nelson Okorie, Kehinde Oyesomi, Babatunde Adeyeye   +4 more
doaj   +1 more source

Pathogens that Cause Illness Clinically Indistinguishable from Lassa Fever, Nigeria, 2018

Emerging Infectious Diseases, 2022
During the 2018 Lassa fever outbreak in Nigeria, samples from patients with suspected Lassa fever but negative Lassa virus PCR results were processed through custom gene expression array cards and metagenomic sequencing.
Jonathan W. Ashcroft, Adebola Olayinka, Nnaemeka Ndodo, Kuiama Lewandowski, Martin D. Curran, Chioma Dan Nwafor, Kingsley Madubuike, Helen Bagnall, Abdulmajid S. Musa, Adama Ahmad, Afolabi Akinpelu, Adesola Adeleye, Chukwuji Martin, Adejoke Akano, Michael Onoja, Akanimo Iniobong, Winifred Ukponu, Chinedu Arinze, Else Ilori, Nwando Mba, Benedict Gannon, Anthony Ahumibe, Chikwe Ihekweazu   +22 more
doaj   +1 more source

AP‐1‐Targeting Decoy Oligonucleotides: Mechanisms and Therapeutic Potential as Modulators of Inflammatory Pathways

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Numerous cellular functions, such as apoptosis, proliferation, differentiation, survival, transformation and cell migration, are regulated by a crucial transcription factor called activator protein 1 (AP‐1). Growing evidence indicates that AP‐1 is involved in severe conditions like fibrosis, cancer, and organ damage, as well as inflammatory ...
Maryam Mahjoubin‐Tehran, Samaneh Rezaei, Vasily N. Sukhorukov, Amin Jalili, Prashant Kesharwani, Amirhossein Sahebkar   +5 more
wiley   +1 more source

What you need to know about Lassa fever [PDF]

Lassa fever is caused by a virus that is found in West Africa. It was first discovered in 1969 in Lassa, Nigeria when two missionary nurses died.Lassa fever is mainly found in Sierra Leone, Liberia, Guinea, and Nigeria and is spread by rats.

core   +2 more sources

Factors associated with a confirmed Lassa fever outbreak in Eguare community of Esan West, Edo State, Nigeria: January-March, 2019

Journal of Interventional Epidemiology and Public Health, 2020
Introduction: Lassa fever disease is endemic in Edo State, Nigeria. A national upsurge in Lassa fever cases and death occurred in January 2019, with Eguare community in Esan West Local Government Area, Edo State having an unusual increase in number of ...
Henry Uguru Ekechi, Charles Ibeneme, Biodun Ogunniyi, Emmanuel Awosanya, Babatunde Gbadebo, Aishatu Usman, Muhammad Shakir Balogun, Celestine Ameh, Lilian Okeke, Chioma Dan-Nwafor, Chikwe Ihekweazu   +10 more
doaj   +1 more source