Results 31 to 40 of about 7,874 (170)

A review of lassa fever outbreaks in Nigeria from 1969 to 2017: Epidemiologic profile, determinants and public health response

Nigerian Journal of Medicine, 2018
Introduction: Lassa fever outbreaks have occurred in Nigeria since the 1969 till date. This is in spite of the fact that the reservoir and modes of transmission have been known for all these years.
T J Okwor, A C Ndu, T A Okeke, S U Arinze-Onyia, A Chinawa, W C Kassy, C N Ochie   +6 more
doaj   +1 more source

Addressing Climate Driven Vector‐Borne Disease in West Africa

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Introduction Vector‐borne diseases (VBDs) pose a significant public health threat in West Africa, contributing to substantial morbidity and mortality, particularly among vulnerable populations. This region is highly susceptible to the effects of climate change due to its geographical location, dependence on rain‐fed agriculture, and fragile ...
Majani Edward, Oladipupo Iyanu Roseline, Emmanuel Victor, Oladeji Yinmi Gabriel   +3 more
wiley   +1 more source

Pathogenic Mechanisms of V. vulnificus and Its Role in the Development of Sepsis

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Sorafenib attenuates urethral scar formation by inhibiting β‐catenin signaling in fibroblasts, which downregulates the SLC7A11/GPX4 antioxidant axis and triggers ferroptosis. This β‐catenin–ferroptosis coupling effectively suppresses fibrogenesis, highlighting sorafenib as a promising drug‐repurposing candidate for urethral stricture.
Zhongying Yu, Xianzhong Zhu, Shijie Tang, Shubo Yang, Jinyu Li, Lianzhong Luo, Yan Tan, Jun Yin   +7 more
wiley   +1 more source

Descriptive epidemiology of Lassa fever, its trend, seasonality, and mortality predictors in Ebonyi State, South- East, Nigeria, 2018—2022

BMC Public Health
Background Nigeria is an epicenter for Lassa fever. Ebonyi state is located in the South-Eastern region of Nigeria where a high burden of Lassa fever has been reported.
Adanna Ezenwa-Ahanene, Adetokunbo T. Salawu, Ayo S. Adebowale   +2 more
doaj   +1 more source

Spreading Speed for a Vector‐Borne Disease System on Non‐Coincident Straight Infinite Cylinders

Studies in Applied Mathematics, Volume 156, Issue 6, June 2026.
ABSTRACT Vector‐borne diseases remain an increasing global public health concern. In this work, we investigate the spreading speed of vector‐borne disease via a four‐component reaction–diffusion system posed on non‐coincident straight infinite cylinders, which stands for an unconventional spatial configuration.
Arnaud Ducrot, Hongliang Li, David Manceau   +2 more
wiley   +1 more source

Pathogens that Cause Illness Clinically Indistinguishable from Lassa Fever, Nigeria, 2018

Emerging Infectious Diseases, 2022
During the 2018 Lassa fever outbreak in Nigeria, samples from patients with suspected Lassa fever but negative Lassa virus PCR results were processed through custom gene expression array cards and metagenomic sequencing.
Jonathan W. Ashcroft, Adebola Olayinka, Nnaemeka Ndodo, Kuiama Lewandowski, Martin D. Curran, Chioma Dan Nwafor, Kingsley Madubuike, Helen Bagnall, Abdulmajid S. Musa, Adama Ahmad, Afolabi Akinpelu, Adesola Adeleye, Chukwuji Martin, Adejoke Akano, Michael Onoja, Akanimo Iniobong, Winifred Ukponu, Chinedu Arinze, Else Ilori, Nwando Mba, Benedict Gannon, Anthony Ahumibe, Chikwe Ihekweazu   +22 more
doaj   +1 more source

Widespread SARS‐CoV‐2 Transmission Despite Limited Reported Cases and Clinical Disease: Exploring the Role of Pre‐Existing Humoral Immunity to SARS‐CoV‐2 in Eastern Sierra Leone

Immunity, Inflammation and Disease, Volume 14, Issue 5, May 2026.
ABSTRACT Background Since December 2019, SARS‐CoV‐2 has infected over 700 million people and caused > 7 million deaths. While much of the global north was severely affected, sub‐Saharan Africa was relatively spared. Possible reasons include a younger population, fewer comorbidities, and pre‐existing immunity.
Robert J. Samuels, Nell G. Bond, Ibrahim Sumah, Donald S. Grant, Mohamed S. Kamara, Lydia Bazzano, Camilo Fernandez, Rodrigo Borrega, Sruti Chandra, Celia R. Glezer, John S. Schieffelin, Troy D. Moon   +11 more
wiley   +1 more source

Factors associated with a confirmed Lassa fever outbreak in Eguare community of Esan West, Edo State, Nigeria: January-March, 2019

Journal of Interventional Epidemiology and Public Health, 2020
Introduction: Lassa fever disease is endemic in Edo State, Nigeria. A national upsurge in Lassa fever cases and death occurred in January 2019, with Eguare community in Esan West Local Government Area, Edo State having an unusual increase in number of ...
Henry Uguru Ekechi, Charles Ibeneme, Biodun Ogunniyi, Emmanuel Awosanya, Babatunde Gbadebo, Aishatu Usman, Muhammad Shakir Balogun, Celestine Ameh, Lilian Okeke, Chioma Dan-Nwafor, Chikwe Ihekweazu   +10 more
doaj   +1 more source

AP‐1‐Targeting Decoy Oligonucleotides: Mechanisms and Therapeutic Potential as Modulators of Inflammatory Pathways

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Numerous cellular functions, such as apoptosis, proliferation, differentiation, survival, transformation and cell migration, are regulated by a crucial transcription factor called activator protein 1 (AP‐1). Growing evidence indicates that AP‐1 is involved in severe conditions like fibrosis, cancer, and organ damage, as well as inflammatory ...
Maryam Mahjoubin‐Tehran, Samaneh Rezaei, Vasily N. Sukhorukov, Amin Jalili, Prashant Kesharwani, Amirhossein Sahebkar   +5 more
wiley   +1 more source

High fatality of Lassa fever outbreak in Kenema District- Sierra Leone, January 2023

Journal of Interventional Epidemiology and Public Health
Introduction: In Sierra Leone, Lassa fever is an endemic disease with an estimated 16% fatality rate among hospitalized cases. On January 16, 2023, the Kenema District Health Management Team received notification about suspected cases of Lassa fever from
Binta Bah, Umaru Nyallay, Philp Gevao, Joel Mansaray, Paul Mansary, Umaru Sesay, Anna Jammeh, Solomon Aiah Sogbeh, Amara Alhaji Sheriff, Joseph Sam Kanu, James Sylvester Squire, Adel Hussein Elduma, Mohamed Alex Vandi, Gebrekrstos Negash Gebru   +13 more
doaj   +1 more source